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Allocryptopine

Name: Allocryptopine
Brand: TargetMol
SKU: T3A2467
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3A2467Cas No. 485-91-6

Alias Thalictrimine, Fagarine I

Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.

Allocryptopine

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Purity: 99.81%

Catalog No. T3A2467Alias Thalictrimine, Fagarine ICas No. 485-91-6

Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$46	In Stock	In Stock
10 mg	$65	In Stock	In Stock
25 mg	$107	In Stock	In Stock
50 mg	$160	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Allocryptopine AI Summary

Allocryptopine shows a range of bioactivities across multiple assays. It demonstrates significant antiplasmodial activity against multi drug-resistant Plasmodium falciparum K1 with an IC50 value of 5080.0 nM, and antiamoebic activity against Entamoeba histolytica NIH 200, with an IC50 value of 135000.0 nM, and another measure at 49.81 ug/mL. It also exhibits cytotoxicity against human KB cells with an IC50 value greater than 338000.0 nM, and antiproliferative activity against human MGC-803 and HGC-27 cells with IC50 values of 109200.0 nM and 97800.0 nM, respectively, though limited activity is noted against human GES1 cells (IC50 > 150000.0 nM). Additionally, it is active as an inhibitor in various systems, including the MLL CXXC domain - DNA interaction (IC50 = 14125.4 nM), Polymerase Iota (IC50 = 100000.0 nM), and as a delayed death inhibitor against malarial parasite plastids after 48-hour incubation (IC50 = 11689.1 nM). For Marburg Virus binding or entry, it shows inhibitory activity with an IC50 of 6309.6 nM, and inhibits TDP-43 (IC50 = 35481.3 nM) and Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with an IC50 of 3162.3 nM. Furthermore, it exhibits competitive inhibition of CYP2D6 enzymes with a Ki value of 122.0 nM using dextromethorphan as the substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Allocryptopine (Thalictrimine) induces muscle contraction and relaxation in urinary bladder and ileum, respectively.
Synonyms	Thalictrimine, Fagarine I

Chemical Properties

Molecular Weight	369.41
Formula	C₂₁H₂₃NO₅
Cas No.	485-91-6
Smiles	O(C)C1=C2C(CC(=O)C=3C(CCN(C)C2)=CC4=C(C3)OCO4)=CC=C1OC
Relative Density.	1.216 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (27.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7070 mL	13.5351 mL	27.0702 mL	135.3510 mL
5 mM	0.5414 mL	2.7070 mL	5.4140 mL	27.0702 mL
10 mM	0.2707 mL	1.3535 mL	2.7070 mL	13.5351 mL
20 mM	0.1354 mL	0.6768 mL	1.3535 mL	6.7675 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc