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Virstatin

Name: Virstatin
Brand: TargetMol
SKU: T50031
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50031Cas No. 88909-96-0

Virstatin is a novel antiviral drug that is a potent inhibitor of viral replication and has been shown to be effective against a wide range of viruses, including herpes simplex virus (HSV), human immunodeficiency virus (HIV) and influenza virus.

Virstatin

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Purity: 99.94%

Catalog No. T50031Cas No. 88909-96-0

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$193	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Virstatin AI Summary

Virstatin is a versatile bioactive molecule that targets various biological processes and pathogens. In the context of Vibrio cholerae O395deltalacZ, it inhibits ToxT-mediated transcriptional activation of multiple promoters (tcpA, acfD, ctxAB, tagA, tcpI, acfA, aldA) with an average inhibitory activity ranging from 3.0% to 15.0% at a concentration of 100 µM. Additionally, Virstatin shows inhibition of sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells, with inhibition rates of 112.71% and 113.05% at 10 µM, respectively, indicating potential as an OATP1B3 and OATP1B1 transporter inhibitor. The compound also exhibits a broad spectrum of bioactivities, including the inhibition of Menin-MLL interactions in leukemia, Chronic Active B-Cell Receptor Signaling, ELG1-dependent DNA repair, malarial parasite plastid, HP1-beta Chromodomain interactions, and Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1). It also demonstrates synthetic lethality in tumor cells producing 2HG and inhibits MBNL1-poly(CUG) RNA binding. In the context of antiviral activity, Virstatin has shown to inhibit cytotoxicity induced by SARS-CoV-2 in various cell lines, such as Caco-2 and VERO-6 cells, at a concentration of 10 µM. It also inhibits the SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of 11.36%, and has shown activity against the SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells. Furthermore, Virstatin demonstrates inhibitory effects against human HDAC6, although with relatively low inhibition percentages of -3.55% and -1.41% using different peptide substrates. Overall, the compound displays a diverse range of bioactivities with potential therapeutic implications in infectious diseases, cancer, and other conditions related to its numerous targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	283.2787
Formula	C₁₆H₁₃NO₄
Cas No.	88909-96-0
Smiles	OC(=O)CCCN1C(=O)C2=CC=CC3=CC=CC(C1=O)=C23
Relative Density.	1.403g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (176.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5301 mL	17.6505 mL	35.3009 mL	176.5046 mL
5 mM	0.7060 mL	3.5301 mL	7.0602 mL	35.3009 mL
10 mM	0.3530 mL	1.7650 mL	3.5301 mL	17.6505 mL
20 mM	0.1765 mL	0.8825 mL	1.7650 mL	8.8252 mL
50 mM	0.0706 mL	0.3530 mL	0.7060 mL	3.5301 mL
100 mM	0.0353 mL	0.1765 mL	0.3530 mL	1.7650 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc