Shopping Cart
Remove All
Your shopping cart is currently empty
Penicillamine
Copy Product Info
😃Good
Catalog No. T0983Cas No. 52-67-5
Alias D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, Artamine
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.
Penicillamine
Copy Product Info😃Good
Purity: 99.8%
Catalog No. T0983Alias D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, ArtamineCas No. 52-67-5
Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 g | $42 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.8%
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
Penicillamine AI Summary
Penicillamine exhibits a broad spectrum of bioactivities with an emphasis on anti-inflammatory, antioxidant, inhibitory, and antiviral properties. Notable anti-inflammatory effects include inhibition of collagen II-induced arthritis in rats, reduction in paw edema, and decreased immune response to collagen II antigen. It also shows significant singlet oxygen and peroxynitrite scavenging activities with respective IC50 values of 4900.0 nM and 5.13 uM, indicating potent antioxidant properties.
In terms of inhibitory activities, Penicillamine inhibits TNF-alpha production, zinc chelation, and cystathionine gamma-lyase with IC50 values indicating variable levels of potency. The compound also manifests considerable inhibitory effects on human liver enzyme activation, sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected cells, and human HDAC6 enzyme, making it a significant multi-target inhibitor.
The antiviral capacity of Penicillamine against SARS-CoV-2 is demonstrated by its inhibitory effects on virus-induced cytotoxicity in Caco-2 and VERO-6 cells, although at a moderate potency with IC50 values greater than 20,000.0 nM.
Despite its therapeutic potential, Penicillamine has shown moderate liver toxicity and has been identified to cause hepatotoxic effects in clinical trials, suggesting caution in its application. The compound's diverse bioactivities and potential therapeutic applications warrant further investigation for optimizing its efficacy and safety profiles..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion. |
| Synonyms | D-penicillamine, Dimethyl Cysteine, D-(-)-Penicillamine, Artamine |
| Molecular Weight | 149.21 |
| Formula | C5H11NO2S |
| Cas No. | 52-67-5 |
| Smiles | CC(C)(S)[C@@H](N)C(O)=O |
| Relative Density. | 1.204g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 1 mg/mL (6.7 mM), Sonication is recommended.  H2O: 71.43 mg/mL (478.72 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
| |||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Penicillamine | purchase Penicillamine | Penicillamine cost | order Penicillamine | Penicillamine chemical structure | Penicillamine formula | Penicillamine molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.