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Anti-ADAMTSL2 Polyclonal Antibody

Catalog No. TMAB-02306 Copy Product Info
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Anti-ADAMTSL2 Polyclonal Antibody is a Rabbit antibody targeting ADAMTSL2. Anti-ADAMTSL2 Polyclonal Antibody can be used in WB.

Anti-ADAMTSL2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-02306

Anti-ADAMTSL2 Polyclonal Antibody is a Rabbit antibody targeting ADAMTSL2. Anti-ADAMTSL2 Polyclonal Antibody can be used in WB.

Anti-ADAMTSL2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2207-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-ADAMTSL2 Polyclonal Antibody is a Rabbit antibody targeting ADAMTSL2. Anti-ADAMTSL2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Verified Activity
Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human HepG2 cell lysates
Primary: Anti-ADAMTSL2 (TMAB-02306) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 102 kDa
Observed band size: 135 kDa
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundADAMTS (A Disintegrin And Metalloproteinase Domain with Thrombospondin type 1 Modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin type 1 (TSP-1) motifs. ADAMTS-L2 (ADAMTS-like protein 2) is a 951 amino acid secreted protein that is highly expressed in lung, kidney and liver. Mutations in the gene encoding ADAMTS are the cause of geleophysic dysplasia, an autosomal recessive disorder characterized by cardiac vavular anomalies, short stature, thick skin and brachydactyly. In individuals affected with geleophysic dysplasia, there is a significant increase in total active TGF-beta 1 and nuclear locations of p-SAMD2 in fibroblasts. Interestingly, ADAMTS-L2 interacts with LTBP-1, a glycoprotein that is part of the platelet-derived TGF-beta 1 complex.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human ADAMTSL2
Antigen Species
Human
Gene Name
ADAMTSL2
Gene ID
Protein Name
ADAMTS-like protein 2
Uniprot ID
Function
Defects in ADAMTSL2 are the cause of geleophysic dysplasia [MIM:231050]. Geleophysic dysplasia is an autosomal recessive disorder characterized by short stature, brachydactyly, thick skin and cardiac valvular anomalies often responsible for an early death.
Chemical Properties
Molecular WeightTheoretical: 102 kDa. Actual: 135 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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