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Thalidomide-O-amido-C6-NH2 TFA

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Catalog No. T17919Cas No. 1950635-14-9
Alias E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFA

Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.

Thalidomide-O-amido-C6-NH2 TFA
Other Forms of Thalidomide-O-amido-C6-NH2 TFA:

Thalidomide-O-amido-C6-NH2 TFA

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Purity: 95.16%
Catalog No. T17919Alias E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFACas No. 1950635-14-9
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$34In StockIn Stock
25 mg$56In StockIn Stock
50 mgPreferentialIn StockIn Stock
1 mL x 10 mM (in DMSO)$43In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:95.16%
Appearance:Solid
Color:White
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.
In vitro
PROTACs consist of two ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
SynonymsE3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, E3 Ligase Ligand-Linker Conjugates 25 TFA, Cereblon Ligand-Linker Conjugates 11 TFA
Chemical Properties
Molecular Weight1087.95
FormulaC46H53F6N8O16
Cas No.1950635-14-9
SmilesO=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)FC1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCCCCCN.C(=O)(C(F)(F)F)O
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 105.5 mg/mL (96.97 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (4.6 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9192 mL4.5958 mL9.1916 mL45.9580 mL
5 mM0.1838 mL0.9192 mL1.8383 mL9.1916 mL
10 mM0.0919 mL0.4596 mL0.9192 mL4.5958 mL
20 mM0.0460 mL0.2298 mL0.4596 mL2.2979 mL
50 mM0.0184 mL0.0919 mL0.1838 mL0.9192 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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