Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 62.00 | |
10 mg | In stock | $ 84.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 187.00 | |
100 mg | In stock | $ 275.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 61.00 |
Description | IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair. |
In vitro | In CD4+CD45RO- T cells, IC 86621 (0 nM, 50 nM, 100 nM) protects rheumatoid arthritis T cells from apoptosis[1]. |
Molecular Weight | 221.25 |
Formula | C12H15NO3 |
CAS No. | 404009-40-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (225.99 mM)
You can also refer to dose conversion for different animals. More
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IC 86621 404009-40-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK ATP Buchwald-Hartwig amination Inhibitor IC-86621 DSB IC86621 antitumor inhibit Apoptosis Fries rearrangement DNA-dependent protein kinase inhibitor