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IC 86621

Name: IC 86621
Brand: TargetMol
SKU: T9760
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9760Cas No. 404009-40-1

IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.

IC 86621

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Purity: 99.68%

Catalog No. T9760Cas No. 404009-40-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$32	In Stock	In Stock
10 mg	$46	In Stock	In Stock
25 mg	$76	In Stock	In Stock
50 mg	$112	In Stock	In Stock
100 mg	$165	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	IC 86621 is a selective and reversible ATP-competitive inhibitor of DNA-PK with an IC50 of 120 nM. IC 86621 increases DNA double-strand break(DSB)-induced antitumor activity with an EC50 of 68 µM for DNA-PK mediated cellular DSB repair.
In vitro	In CD4+CD45RO- T cells, IC 86621 (0 nM, 50 nM, 100 nM) protects rheumatoid arthritis T cells from apoptosis[1].

Chemical Properties

Molecular Weight	221.25
Formula	C₁₂H₁₅NO₃
Cas No.	404009-40-1
Smiles	CC(=O)c1ccc(cc1O)N1CCOCC1
Relative Density.	1.210 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (225.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5198 mL	22.5989 mL	45.1977 mL	225.9887 mL
5 mM	0.9040 mL	4.5198 mL	9.0395 mL	45.1977 mL
10 mM	0.4520 mL	2.2599 mL	4.5198 mL	22.5989 mL
20 mM	0.2260 mL	1.1299 mL	2.2599 mL	11.2994 mL
50 mM	0.0904 mL	0.4520 mL	0.9040 mL	4.5198 mL
100 mM	0.0452 mL	0.2260 mL	0.4520 mL	2.2599 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc