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AZD5423

Name: AZD5423
Brand: TargetMol
SKU: T14377
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14377Cas No. 1034148-04-3

AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of the glucocorticoid receptor (GR) that effectively reduces allergen-induced responses in individuals with mild allergic asthma.

AZD5423

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Purity: 98.76%

Catalog No. T14377Cas No. 1034148-04-3

AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of the glucocorticoid receptor (GR) that effectively reduces allergen-induced responses in individuals with mild allergic asthma.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$263	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.76%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of the glucocorticoid receptor (GR) that effectively reduces allergen-induced responses in individuals with mild allergic asthma.
In vitro	AZD5423 exhibits high affinity for the glucocorticoid receptor, with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and demonstrates over 900-fold selectivity towards other steroid hormone receptors[1].

Chemical Properties

Molecular Weight	487.45
Formula	C₂₅H₂₁F₄N₃O₃
Cas No.	1034148-04-3
Smiles	COc1cccc(c1)[C@@H](Oc1ccc2n(ncc2c1)-c1ccc(F)cc1)[C@H](C)NC(=O)C(F)(F)F
Relative Density.	1.33 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (205.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0515 mL	10.2575 mL	20.5149 mL	102.5746 mL
5 mM	0.4103 mL	2.0515 mL	4.1030 mL	20.5149 mL
10 mM	0.2051 mL	1.0257 mL	2.0515 mL	10.2575 mL
20 mM	0.1026 mL	0.5129 mL	1.0257 mL	5.1287 mL
50 mM	0.0410 mL	0.2051 mL	0.4103 mL	2.0515 mL
100 mM	0.0205 mL	0.1026 mL	0.2051 mL	1.0257 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc