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Anti-SEMA4D Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting SEMA4D. Anti-SEMA4D Monoclonal Antibody-Biotin can be used in ELISA, FACS.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 μg | $195 | 12 days | |
50 μg | $234 | 12 days | |
100 μg | $327 | 12 days |
Description | Anti-SEMA4D Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting SEMA4D. Anti-SEMA4D Monoclonal Antibody-Biotin can be used in ELISA, FACS. |
Alias | Semaphorin-4D, GR3, BB18, A8 |
Ig Type | Rabbit monoclonal IgG |
Reactivity | Human |
Verified Activity | Flow cytometry analysis of SEMA4D overexpressed 293F cells with TMAZ-0130BBI, followed by goat anti-rabbit IgG-ABflo 647 (red). The isotype control is rabbit IgG (black line). |
Application | ELISA, FACS |
Recommended Dose | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Subcellular Localization | Single-pass type I membrane |
Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of SEMA4D protein. |
Purification | Protein A Affinity Purified |
Appearance | Liquid |
Formulation | 0.22 μm filtered solution in PBS. |
Purity | > 95% as determined by SDS-PAGE. |
Research Background | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed: 20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed: 19788569). Promotes the migration of cerebellar granule cells (PubMed: 16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed: 8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed: 16055703) |
Conjucates | Biotin |
Others Formats | Unconjugated |
Antibody Types Available | 2 |
Immunogen | SEMA4D |
Antigen Species | Human |
Gene ID | 10507 |
Uniprot ID | |
Biology Area | Cancer Research |
Molecular Weight | 150 kDa |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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