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Albendazole sulfoxide

Name: Albendazole sulfoxide
Brand: TargetMol
SKU: T6372
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6372Cas No. 54029-12-8

Alias Ricobendazole, Albendazole Oxide

Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.

Albendazole sulfoxide

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Purity: 97.29%

Catalog No. T6372Alias Ricobendazole, Albendazole OxideCas No. 54029-12-8

Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.29%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Albendazole sulfoxide AI Summary

Albendazole sulfoxide exhibits a diverse array of bioactivities. It shows significant antiparasitic activity against Taenia crassiceps cysts with varying levels of mortality observed over 11 days, evaluated using the Trypan blue exclusion test. The compound has an octanol-water partition coefficient of 1.54, indicating its lipophilic nature. In molecular biology assays, Albendazole sulfoxide strongly inhibits mouse Ido2 in HEK293T cells, inhibiting 55.0% or more of kynurenine formation at a concentration of 20 µM after 45 minutes. Additionally, it demonstrates antiproliferative action against Plasmodium falciparum strains 3D7, DD2, and HB3 with potencies ranging from 2.7 nM to 11875.4 nM. It also blocks Ebola Virus entry, showing AC50 values from 0.631 µM to 11.22 µM. Albendazole sulfoxide targets SARS-CoV-2 by reducing induced cytotoxicity in Caco-2 cells with an inhibition of -13.62% at 10 µM concentration after 48 hours, and simultaneously inhibits SARS-CoV-2 3CL-Pro protease activity by -6.179% at 20 µM. In VERO-6 cell assays, it inhibits SARS-CoV-2 with an inhibition rate of 0.16% at 10 µM over 48 hours. Finally, Albendazole sulfoxide inhibits human HDAC6 enzyme activity more effectively with a custom peptide substrate (68.86% inhibition) compared to a commercial peptide substrate (18.58% inhibition), indicating potential as a histone deacetylase inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.
Synonyms	Ricobendazole, Albendazole Oxide

Chemical Properties

Molecular Weight	281.33
Formula	C₁₂H₁₅N₃O₃S
Cas No.	54029-12-8
Smiles	CCCS(=O)C1=CC=C2N=C(NC(=O)OC)NC2=C1
Relative Density.	1.458g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33 mg/mL (117.3 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5545 mL	17.7727 mL	35.5454 mL	177.7272 mL
5 mM	0.7109 mL	3.5545 mL	7.1091 mL	35.5454 mL
10 mM	0.3555 mL	1.7773 mL	3.5545 mL	17.7727 mL
20 mM	0.1777 mL	0.8886 mL	1.7773 mL	8.8864 mL
50 mM	0.0711 mL	0.3555 mL	0.7109 mL	3.5545 mL
100 mM	0.0355 mL	0.1777 mL	0.3555 mL	1.7773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc