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Anti-CD3 epsilon/CD3e Antibody (8R486)
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Catalog No. TMAH-00195
Alias TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon
Anti-CD3 epsilon/CD3e Antibody (8R486) is an antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (8R486) can be used in ELISA, FCM.
Anti-CD3 epsilon/CD3e Antibody (8R486)
Anti-CD3 epsilon/CD3e Antibody (8R486)
😃Good
Catalog No. TMAH-00195Alias TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon
Anti-CD3 epsilon/CD3e Antibody (8R486) is an antibody targeting CD3 epsilon/CD3e. Anti-CD3 epsilon/CD3e Antibody (8R486) can be used in ELISA, FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Mouse Monoclonal Application: ELISA, FCM Reactivity: Human |
| Alias | TCRE, T3E, IMD18, CD3e molecule, ε (CD3-TCR complex), CD3e molecule, epsilon (CD3-TCR complex), CD3 ε/CD3e, CD3 ε, CD3 epsilon |
| Ig Type | Mouse IgG2a |
| Clone | 8R486 |
| Reactivity | Human |
| Verified Activity | Overlay Peak curve showing JK cells surface stained with TMAH-00195 (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10^6 cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10^6 cells) used under the same conditions. Acquisition of >10, 006 events was performed. |
| Application | ELISA, FCM |
| Recommended Dose | FCM:1:20-1:500. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CD3E Protein |
| Antigen Species | Human |
| Gene ID | 916 |
| Uniprot ID | |
| Biology Area | Immunology, Stem cells |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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