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Anti-LAG3 Antibody (5Y626)
😃Good
Catalog No. TMAH-00682
Alias lymphocyte-activation gene 3, LAG-3, CD223
Anti-LAG3 Antibody (5Y626) is an antibody targeting LAG3. Anti-LAG3 Antibody (5Y626) can be used in ELISA, IHC.
Anti-LAG3 Antibody (5Y626)
Anti-LAG3 Antibody (5Y626)
😃Good
Catalog No. TMAH-00682Alias lymphocyte-activation gene 3, LAG-3, CD223
Anti-LAG3 Antibody (5Y626) is an antibody targeting LAG3. Anti-LAG3 Antibody (5Y626) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
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Antigen Details
Chemical Properties
| Description | Anti-LAG3 Antibody (5Y626) is an antibody targeting LAG3. Anti-LAG3 Antibody (5Y626) can be used in ELISA, IHC. |
| Alias | lymphocyte-activation gene 3, LAG-3, CD223 |
| Ig Type | hIgG1 |
| Clone | 5Y626 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-00682 diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. 2. The Binding Activity of Human LAG3 with Anti-LAG3 Recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LAG3 at 2 μg/mL can bind Anti-LAG3 recombinant antibody. The EC50 is 2.306-2.731 ng/mL. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein.; [Secreted lymphocyte activation gene 3 protein]: Secreted. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| Research Background | Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear. May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human LAG3 Protein |
| Antigen Species | Human |
| Gene ID | 3902 |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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