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Endoxifen (Z-isomer)

Name: Endoxifen (Z-isomer)
Brand: TargetMol
SKU: T2280
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2280Cas No. 112093-28-4

Alias Endoxifen Z-isomer

Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.

Endoxifen (Z-isomer)

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Purity: 99.81%

Catalog No. T2280Alias Endoxifen Z-isomerCas No. 112093-28-4

Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$64	In Stock
10 mg	$85	In Stock
25 mg	$179	In Stock
50 mg	$288	In Stock
100 mg	$432	In Stock
200 mg	$626	In Stock
1 mL x 10 mM (in DMSO)	$73	In Stock

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Batch Information

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Purity:99.81%

Resource Download

COA LCMS HPLC

Product Introduction

Bioactivity

Description	Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptors that also inhibits aromatase activity.
Targets&IC50	ERG (human):1.6 μM
Synonyms	Endoxifen Z-isomer

Chemical Properties

Molecular Weight	373.49
Formula	C₂₅H₂₇NO₂
Cas No.	112093-28-4
Smiles	CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1
Relative Density.	1.099g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (120.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6774 mL	13.3872 mL	26.7745 mL	133.8724 mL
5 mM	0.5355 mL	2.6774 mL	5.3549 mL	26.7745 mL
10 mM	0.2677 mL	1.3387 mL	2.6774 mL	13.3872 mL
20 mM	0.1339 mL	0.6694 mL	1.3387 mL	6.6936 mL
50 mM	0.0535 mL	0.2677 mL	0.5355 mL	2.6774 mL
100 mM	0.0268 mL	0.1339 mL	0.2677 mL	1.3387 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc