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All-trans-retinal

Name: All-trans-retinal
Brand: TargetMol
SKU: T5256
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5256Cas No. 116-31-4

Alias Vitamin A aldehyde, Retinaldehyde, All trans-Retinal

All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.

All-trans-retinal

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Purity: 98.70%

Catalog No. T5256Alias Vitamin A aldehyde, Retinaldehyde, All trans-RetinalCas No. 116-31-4

All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$30	-	In Stock
50 mg	$40	-	In Stock
100 mg	$56	-	In Stock
500 mg	$113	-	In Stock
1 g	$172	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.70%

Color:Orange

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COA LCMS HNMR

Product Introduction

All-trans-retinal AI Summary

All-trans-retinal exhibits significant bioactivity across various biological and biochemical assays. It demonstrates the ability to act on multiple enzymatic targets such as human AKR1B1 and various forms of the human AKR1B10 enzyme, indicating diverse kinetic properties. Specifically, it affects AKR1B1 with a Km of 1100 µM and Kcat/Km of 320 /mM/min, while notably enhancing the activity of wild type AKR1B10 with much higher specificity (Km = 600 µM, Kcat/Km = 45000 /mM/min) compared to its mutants. In cell-based assays, All-trans-retinal induces the morphological transformation of rat ASK cells into astrocytes, presenting an ED50 of less than 10 µM. It influences cellular ATP levels with significant potency, ranging from 12.6 nM to 100 µM, and exhibits bioactivity measured through luminescent assays. In antiviral assays, All-trans-retinal shows inhibitory activity against SARS-CoV-2 in different cellular contexts. It inhibits cytotoxicity in Caco-2 cells at 10 µM (-3.71%), and also displays activity in HRCE cells with a hit score of 0.3836. Despite varying inhibition percentages against SARS-CoV-2 3CL-Pro protease and viral cytotoxicity in VERO-6 cells, it consistently demonstrates an antiviral profile. Additionally, All-trans-retinal inhibits alpha-synuclein fibril formation and amyloid beta (1-40) with IC50 values of 190 nM and 180 nM, respectively. It also acts as an inverse agonist at TLX with an EC50 of 200 nM and shows substantial inhibitory effects (55%) on transglutaminase activity in human keratinocytes at 1 µM. Overall, All-trans-retinal emerges as a multifaceted bioactive molecule with enzymatic, antiviral, neuroprotective, and cellular pathway modulation properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	All-trans-retinal (Vitamin A aldehyde) is a one of the major vitamin A metabolites in the retina. All-trans-RAL is regenerated to the visual chromophore, 11-cis-retinal in physiological conditions.
Synonyms	Vitamin A aldehyde, Retinaldehyde, All trans-Retinal

Chemical Properties

Molecular Weight	284.44
Formula	C₂₀H₂₈O
Cas No.	116-31-4
Smiles	C\C(\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)=C/C=O
Relative Density.	0.948g/cm3

Storage & Solubility Information

Storage

store at low temperature,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 25 mg/mL (87.89 mM), Sonication is recommended. (The compound is unstable in solution, please use soon.)

DMSO: 240 mg/mL (843.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5157 mL	17.5784 mL	35.1568 mL	175.7840 mL
5 mM	0.7031 mL	3.5157 mL	7.0314 mL	35.1568 mL
10 mM	0.3516 mL	1.7578 mL	3.5157 mL	17.5784 mL
20 mM	0.1758 mL	0.8789 mL	1.7578 mL	8.7892 mL
50 mM	0.0703 mL	0.3516 mL	0.7031 mL	3.5157 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0352 mL	0.1758 mL	0.3516 mL	1.7578 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc