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PAβN dihydrochloride

🥰Excellent
Catalog No. T12374Cas No. 100929-99-5
Alias Phe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochloride

PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.

PAβN dihydrochloride

PAβN dihydrochloride

🥰Excellent
Purity: 99.82%
Catalog No. T12374Alias Phe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochlorideCas No. 100929-99-5
PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$35In StockIn Stock
10 mg$57In StockIn Stock
25 mg$105In StockIn Stock
50 mg$147In StockIn Stock
100 mg$198In StockIn Stock
1 mL x 10 mM (in DMSO)$40In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.82%
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Product Introduction

Bioactivity
Description
PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.
In vitro
PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates[2].
SynonymsPhe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochloride
Chemical Properties
Molecular Weight519.47
FormulaC25H32Cl2N6O2
Cas No.100929-99-5
SmilesCl.Cl.N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc2ccccc2c1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 14.29 mg/mL (27.51 mM), Sonication is recommended.
DMSO: 95 mg/mL (182.88 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.35 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.9250 mL9.6252 mL19.2504 mL96.2519 mL
5 mM0.3850 mL1.9250 mL3.8501 mL19.2504 mL
10 mM0.1925 mL0.9625 mL1.9250 mL9.6252 mL
20 mM0.0963 mL0.4813 mL0.9625 mL4.8126 mL
DMSO
1mg5mg10mg50mg
50 mM0.0385 mL0.1925 mL0.3850 mL1.9250 mL
100 mM0.0193 mL0.0963 mL0.1925 mL0.9625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Phe-Arg-β-naphthylamide DihydrochloridePhe-Arg-β-naphthylamidePhe-Arg-b-naphthylamide DihydrochloridePhe-Arg-b-naphthylamidePhe-Arg-beta-naphthylamide DihydrochloridePhe-Arg-beta-naphthylamidePAβN DihydrochloridePAβN dihydrochloridePAβNPAbN DihydrochloridePAbNPAbetaN DihydrochloridePAbetaNMC-207,110 DihydrochlorideMC-207,110Inhibitorinhibitefflux pumpBacterial
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