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PAβN dihydrochloride

Name: PAβN dihydrochloride
Brand: TargetMol
SKU: T12374
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12374Cas No. 100929-99-5

Alias Phe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochloride

PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.

PAβN dihydrochloride

🥰Excellent

Purity: 99.82%

Catalog No. T12374Alias Phe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochlorideCas No. 100929-99-5

PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$57	In Stock	In Stock
25 mg	$105	In Stock	In Stock
50 mg	$147	In Stock	In Stock
100 mg	$198	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$40	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.
In vitro	PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates[2].
Synonyms	Phe-Arg-β-naphthylamide dihydrochloride, MC-207,110 dihydrochloride

Chemical Properties

Molecular Weight	519.47
Formula	C₂₅H₃₂Cl₂N₆O₂
Cas No.	100929-99-5
Smiles	Cl.Cl.N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc2ccccc2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 14.29 mg/mL (27.51 mM), Sonication is recommended.

DMSO: 95 mg/mL (182.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9250 mL	9.6252 mL	19.2504 mL	96.2519 mL
5 mM	0.3850 mL	1.9250 mL	3.8501 mL	19.2504 mL
10 mM	0.1925 mL	0.9625 mL	1.9250 mL	9.6252 mL
20 mM	0.0963 mL	0.4813 mL	0.9625 mL	4.8126 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0385 mL	0.1925 mL	0.3850 mL	1.9250 mL
100 mM	0.0193 mL	0.0963 mL	0.1925 mL	0.9625 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc