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Isoacteoside

Name: Isoacteoside
Brand: TargetMol
SKU: T3892
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3892Cas No. 61303-13-7

Alias Isoverbascoside

Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.

Isoacteoside

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Purity: 99.48%

Catalog No. T3892Alias IsoverbascosideCas No. 61303-13-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$65	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$176	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$389	In Stock	In Stock
200 mg	$573	In Stock	-
1 mL x 10 mM (in DMSO)	$91	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.48%

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Isoacteoside AI Summary

Isoacteoside exhibits multifaceted bioactivity including cytotoxicity, antioxidant, antiviral, immunomodulatory, hepatoprotective, MMP inhibitory, and antifungal properties. It shows cytotoxicity against mouse P388 cells with an ED50 of 10.0 µg/mL. Its antioxidant activities include DPPH free radical scavenging with an IC50 range of 0.16 µg/mL to 1300.0 nM, protection against peroxyl radical-induced alkaline phosphatase activity loss with an EC50 of 1200.0 nM, and ABTS radical scavenging with a Trolox equivalent activity of 1.228. The compound also exhibits significant antiviral activity against RSV, showing EC50 values of 1.1 µg/mL and 0.62 µg/mL against RSV A-2 and RSV-long infected human Hep2 cells, respectively, coupled with low cytotoxicity (IC50 ranging from 27.0 to 125.0 µg/mL). Additionally, Isoacteoside promotes IL6 production in human PBMCs without inducing IL12 or TNFα. It demonstrates hepatoprotective effects in both cell culture and animal models, notably against D-galactosamine-induced cytotoxicity and lipopolysaccharide-induced liver injury. Moreover, it inhibits nitric oxide and TNFα production in mouse peritoneal macrophages, though with IC50 values greater than 100,000.0 nM. In terms of enzyme inhibition, the compound shows substantial inhibitory effects on multiple matrix metalloproteinases, particularly MMP2 and MMP12, with IC50 values indicating potent inhibition. Lastly, Isoacteoside possesses antifungal activity against Cryptococcus neoformans with a MIC greater than 125.0 µg/mL..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Isoacteoside has the anti-inflammatory effect, mediated by action on caspase-1, mitogen-activated protein kinases (c-Jun N-terminal kinase, p38, extracellular signal-regulated protein kinase) and nuclear factor-kappa B pathways.
Synonyms	Isoverbascoside

Chemical Properties

Molecular Weight	624.59
Formula	C₂₉H₃₆O₁₅
Cas No.	61303-13-7
Smiles	C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](COC(=O)\C=C\c3ccc(O)c(O)c3)O[C@@H](OCCc3ccc(O)c(O)c3)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.60 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (96.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6011 mL	8.0053 mL	16.0105 mL	80.0525 mL
5 mM	0.3202 mL	1.6011 mL	3.2021 mL	16.0105 mL
10 mM	0.1601 mL	0.8005 mL	1.6011 mL	8.0053 mL
20 mM	0.0801 mL	0.4003 mL	0.8005 mL	4.0026 mL
50 mM	0.0320 mL	0.1601 mL	0.3202 mL	1.6011 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc