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DHODH-IN-16

Name: DHODH-IN-16
Brand: TargetMol
SKU: T40168
Price: 189 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40168Cas No. 2511248-11-4

DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).

DHODH-IN-16

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Purity: 99.64%

Catalog No. T40168Cas No. 2511248-11-4

DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).

Pack Size	Price	Availability
1 mg	$69	In Stock
5 mg	$172	In Stock
10 mg	Preferential	In Stock
25 mg	Preferential	In Stock
50 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$189	In Stock

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Batch Information

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Purity:99.64%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).
Targets&IC50	DHODH:0.2 nM(MOLM-13 cells), DHODH (human):0.396 nM
In vitro	DHODH-IN-16 inhibited the growth of MOLM-13 cells effectively (IC50 = 0.2 nM) [1] .

Chemical Properties

Molecular Weight	436.48
Formula	C₂₄H₂₅FN₄O₃
Cas No.	2511248-11-4
Smiles	CCn1c(CO)nn(-c2cc3c(cn(-c4ccccc4C)c(=O)c3cc2F)C(C)C)c1=O
Relative Density.	1.31 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 95 mg/mL (217.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2911 mL	11.4553 mL	22.9106 mL	114.5528 mL
5 mM	0.4582 mL	2.2911 mL	4.5821 mL	22.9106 mL
10 mM	0.2291 mL	1.1455 mL	2.2911 mL	11.4553 mL
20 mM	0.1146 mL	0.5728 mL	1.1455 mL	5.7276 mL
50 mM	0.0458 mL	0.2291 mL	0.4582 mL	2.2911 mL
100 mM	0.0229 mL	0.1146 mL	0.2291 mL	1.1455 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc