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VUF10460

🥰Excellent
Catalog No. T3963Cas No. 1028327-66-3

VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies.

VUF10460

VUF10460

🥰Excellent
Purity: 99.57%
Catalog No. T3963Cas No. 1028327-66-3
VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies.
Pack SizePriceAvailabilityQuantity
5 mg$29In Stock
10 mg$49In Stock
25 mg$98In Stock
50 mg$173In Stock
100 mg$270In Stock
200 mg$398In Stock
1 mL x 10 mM (in DMSO)$34In Stock
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Purity:99.57%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies.
Targets&IC50
H4 receptor:7.46(pKi)
In vitro
UF10460 exhibits binding affinities to rat H3 and H4 receptors with pKi values of 5.75 and 7.46, respectively, whereas VUF10460 demonstrates approximately 50-fold selectivity for the rat H4 receptor over the H3 receptor [1].
In vivo
HCl-induced rat gastric lesions are significantly enhanced by the H4 receptor agonist VUF10460, an effect not altered by the H4 receptor antagonist JNJ7777120[1]. VUF10460 exhibits approximately 50-fold selectivity for the rat H(4) receptor over the H(3) receptor.
Chemical Properties
Molecular Weight269.34
FormulaC15H19N5
Cas No.1028327-66-3
SmilesCN1CCN(CC1)c1cc(nc(N)n1)-c1ccccc1
Relative Density.1.187 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (167.08 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7128 mL18.5639 mL37.1278 mL185.6390 mL
5 mM0.7426 mL3.7128 mL7.4256 mL37.1278 mL
10 mM0.3713 mL1.8564 mL3.7128 mL18.5639 mL
20 mM0.1856 mL0.9282 mL1.8564 mL9.2819 mL
50 mM0.0743 mL0.3713 mL0.7426 mL3.7128 mL
100 mM0.0371 mL0.1856 mL0.3713 mL1.8564 mL

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Keywords

VUF-10460VUF10460VUF 10460InhibitorinhibitHistamineReceptorHistamine ReceptorH4 receptor
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