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VUF10460

Name: VUF10460
Brand: TargetMol
SKU: T3963
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3963Cas No. 1028327-66-3

VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies.

VUF10460

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Purity: 99.57%

Catalog No. T3963Cas No. 1028327-66-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$29	In Stock	In Stock
10 mg	$49	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$270	In Stock	In Stock
200 mg	$398	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	VUF10460, a non-imidazole histamine H4 receptor agonist, [58C8-51-20-3] is structurally classified under the chlorobenzylpiperazine ethers with the IUPAC designation (2-[(2-chlorophenyl)methyl]-1-piperazinyl)(1H-indol-3-yl)methanone. It is typically utilized in pharmacological research and exhibits specificity for the H4 subtype, making it a valuable tool in immunological studies.
Targets&IC50	H4 receptor:7.46(pKi)
In vitro	UF10460 exhibits binding affinities to rat H3 and H4 receptors with pKi values of 5.75 and 7.46, respectively, whereas VUF10460 demonstrates approximately 50-fold selectivity for the rat H4 receptor over the H3 receptor [1].
In vivo	HCl-induced rat gastric lesions are significantly enhanced by the H4 receptor agonist VUF10460, an effect not altered by the H4 receptor antagonist JNJ7777120[1]. VUF10460 exhibits approximately 50-fold selectivity for the rat H(4) receptor over the H(3) receptor.

Chemical Properties

Molecular Weight	269.34
Formula	C₁₅H₁₉N₅
Cas No.	1028327-66-3
Smiles	CN1CCN(CC1)c1cc(nc(N)n1)-c1ccccc1
Relative Density.	1.187 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (167.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7128 mL	18.5639 mL	37.1278 mL	185.6390 mL
5 mM	0.7426 mL	3.7128 mL	7.4256 mL	37.1278 mL
10 mM	0.3713 mL	1.8564 mL	3.7128 mL	18.5639 mL
20 mM	0.1856 mL	0.9282 mL	1.8564 mL	9.2819 mL
50 mM	0.0743 mL	0.3713 mL	0.7426 mL	3.7128 mL
100 mM	0.0371 mL	0.1856 mL	0.3713 mL	1.8564 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc