Shopping Cart
- Remove All
- Your shopping cart is currently empty
Anti-DR5/TRAIL R2 Antibody (7G818) is a Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody (7G818) can be used in ELISA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $269 | 7-10 days |
Description | Anti-DR5/TRAIL R2 Antibody (7G818) is a Rabbit antibody targeting DR5/TRAIL R2. Anti-DR5/TRAIL R2 Antibody (7G818) can be used in ELISA. |
Alias | ZTNFR9, tumor necrosis factor receptor superfamily, member 10b, TRICKB, TRICK2B, TRICK2A, TRICK2, TRAIL-R2, TRAILR2, KILLER/DR5, KILLER, DR5, CD262 |
Ig Type | Monoclonal Rabbit IgG |
Clone | 7G818 |
Reactivity | Mouse |
Application | ELISA |
Recommended Dose | ELISA: 1:5000-1:10000 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 (rM TRAIL R2 / TNFRSF10B / CD262; TMPY-01437; NP_064671.2; Met 1-Ser 177). |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Immunogen | Recombinant Mouse TRAIL R2 / TNFRSF10B / CD262 protein (TMPY-01437) |
Antigen Species | Mouse |
Biology Area | Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.