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Ethoxyquin

Name: Ethoxyquin
Brand: TargetMol
SKU: T0756
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0756Cas No. 91-53-2

Alias Santoquin, Santoflex, Quinol

Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.

Ethoxyquin

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Purity: 98.73%

Catalog No. T0756Alias Santoquin, Santoflex, QuinolCas No. 91-53-2

Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.73%

Appearance:Liquid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Ethoxyquin AI Summary

Ethoxyquin shows a concentration of 0.41 μM that produces 50% protection against L-HCA-mediated neurotoxicity in the HT-22 hippocampal cell line and a minimum tolerated concentration of 50.0 μM according to the MTT reduction assay in the same cell line. A concentration of 103.0 μM leads to 50% toxicity. The safety ratio of the minimum tolerated concentration to the concentration producing 50% protection is 122.0. After intraperitoneal administration of 150 mg/kg, there is an 80.0% survival rate in NMRI mice, with a body temperature decrease of 1.85 degrees Celsius after 30 minutes. Furthermore, Ethoxyquin acts as a potent inhibitor targeting the Menin-MLL Interaction in MLL-related leukemias, modulates Lamin A splicing, affects cell viability in multiple assays, and inhibits various enzymes such as HSD17B4, JMJD2E, and Tyrosyl-DNA Phosphodiesterase. It affects several receptors and signaling pathways, including retinoid X receptor, estrogen receptor, androgen receptor, peroxisome proliferator-activated receptors, and p53 signaling. The compound shows activity against targets like HIV-1 protein Vpr and Trypanosoma brucei and participates in processes like DNA re-replication and gametocytocidal effects. Additionally, Ethoxyquin inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, with an inhibition percentage of 108.27% and 119.72%, respectively, at a concentration of 10 μM. Lastly, it shows lower activity relative to arbidol control in Vero E6 cells infected with SARS-CoV-2, with an inhibition index of 0.6516 after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.
Synonyms	Santoquin, Santoflex, Quinol

Chemical Properties

Molecular Weight	217.31
Formula	C₁₄H₁₉NO
Cas No.	91-53-2
Smiles	CCOc1ccc2NC(C)(C)C=C(C)c2c1
Relative Density.	1.03

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1150.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (15.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6017 mL	23.0086 mL	46.0172 mL	230.0861 mL
5 mM	0.9203 mL	4.6017 mL	9.2034 mL	46.0172 mL
10 mM	0.4602 mL	2.3009 mL	4.6017 mL	23.0086 mL
20 mM	0.2301 mL	1.1504 mL	2.3009 mL	11.5043 mL
50 mM	0.0920 mL	0.4602 mL	0.9203 mL	4.6017 mL
100 mM	0.0460 mL	0.2301 mL	0.4602 mL	2.3009 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc