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Anti-LDLR Antibody (6D902)

😃Good
Catalog No. TMAY-03220
Alias low density lipoprotein receptor, LDLCQ2, LDL Receptor, LDL R, FHC, FH

Anti-LDLR Antibody (6D902) is a Rabbit antibody targeting LDLR. Anti-LDLR Antibody (6D902) can be used in ICC/IF.

Anti-LDLR Antibody (6D902)

Anti-LDLR Antibody (6D902)

😃Good
Catalog No. TMAY-03220Alias low density lipoprotein receptor, LDLCQ2, LDL Receptor, LDL R, FHC, FH
Anti-LDLR Antibody (6D902) is a Rabbit antibody targeting LDLR. Anti-LDLR Antibody (6D902) can be used in ICC/IF.
Pack SizePriceAvailabilityQuantity
20 μL$92 7-10 days
100 μL$294 7-10 days
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Product Introduction

Bioactivity
Description
Anti-LDLR Antibody (6D902) is a Rabbit antibody targeting LDLR. Anti-LDLR Antibody (6D902) can be used in ICC/IF.
Aliaslow density lipoprotein receptor, LDLCQ2, LDL Receptor, LDL R, FHC, FH
Ig Type
Monoclonal Rabbit IgG
Clone
6D902
Reactivity
Mouse
Verified Activity
Immunofluorescence staining of mLDLR in RAW264.7 cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-mouse mLDLR monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm .
Application
ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse LDLR (rM LDLR; TMPY-01014; NP_034830.2; Met1-Arg790).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundLDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Mouse LDLR Protein (TMPY-01014)
Antigen Species
Mouse
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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