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Anti-PSME2 Antibody (7S935)
(Synonyms: REGβ, REGbeta, proteasome (prosome, macropain) activator subunit 2 (PA28 β), proteasome (prosome, macropain) activator subunit 2 (PA28 beta), PA28β, PA28beta, PA28B) Copy Product Info
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Synonyms: REGβ, REGbeta, proteasome (prosome, macropain) activator subunit 2 (PA28 β), proteasome (prosome, macropain) activator subunit 2 (PA28 beta), PA28β, PA28beta, PA28B
Catalog No. TMAY-02763 Copy Product Info
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Anti-PSME2 Antibody (7S935) is a Mouse antibody targeting PSME2. Anti-PSME2 Antibody (7S935) can be used in ELISA,IP,WB.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $198 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-PSME2 Antibody (7S935) is a Mouse antibody targeting PSME2. Anti-PSME2 Antibody (7S935) can be used in ELISA,IP,WB. |
| Synonyms | REGβ, REGbeta, proteasome (prosome, macropain) activator subunit 2 (PA28 β), proteasome (prosome, macropain) activator subunit 2 (PA28 beta), PA28β, PA28beta, PA28B |
| Ig Type | Mouse IgG1 |
| Clone | 7S935 |
| Reactivity | Human |
| Specificity | Human PSME2 No cross-reactivity in ELISA with E.coli cell lysate |
| Application | |
| Recommended Dose | WB: 1:500-1:2000; ELISA: 1:1000-1:2000; IP: 1-4 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PSME2 / PA28b (rh PSME2 / PA28b; TMPY-03610; Met1-Tyr239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 1 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME2 gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PSME2 / PA28b protein (TMPY-03610) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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