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TBI-223
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Catalog No. T37350Cas No. 2071265-08-0
Alias TBI 223
TBI-223 is an orally effective antibiotic and antibacterial agent active against Mycobacterium tuberculosis. It demonstrates efficacy against methicillin-resistant Staphylococcus aureus infections in mouse interference models and is applicable for tuberculosis research.
TBI-223
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Purity: 99.78%
Catalog No. T37350Alias TBI 223Cas No. 2071265-08-0
TBI-223 is an orally effective antibiotic and antibacterial agent active against Mycobacterium tuberculosis. It demonstrates efficacy against methicillin-resistant Staphylococcus aureus infections in mouse interference models and is applicable for tuberculosis research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $132 | - | In Stock | |
| 5 mg | $328 | - | In Stock | |
| 10 mg | $562 | - | In Stock | |
| 25 mg | $1,090 | - | In Stock | |
| 50 mg | $1,820 | - | In Stock | |
| 100 mg | $2,630 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $363 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.78%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TBI-223 is an orally effective antibiotic and antibacterial agent active against Mycobacterium tuberculosis. It demonstrates efficacy against methicillin-resistant Staphylococcus aureus infections in mouse interference models and is applicable for tuberculosis research. |
| In vitro | In 7H9 medium, the half-maximal inhibitory concentration (MIC₅₀) values of TBI-223 against Mycobacterium tuberculosis, Mycobacterium kansasii, MAC, and MAbC were 1.50 μg/mL, 2.00 μg/mL, 8.00 μg/mL, and 2.00 μg/mL, respectively [1]. |
| In vivo | TBI-223 (80-160 mg/kg, orally administered twice daily for 7 days) achieved a 100% survival rate in the MRSA bacteremia model of C57BL/6 mice [2]. TBI-223 (80-160 mg/kg, orally administered twice daily for 7 days) significantly reduced the infected lesion area in the MRSA skin wound infection model of both non-diabetic C57BL/6 mice and diabetic TallyHo/JngJ mice [2]. TBI-223 (80-160 mg/kg, orally administered twice daily for 7 days) significantly decreased the bioluminescence imaging (BLI) signal intensity in the MRSA orthopedic implant-associated infection model of C57BL/6 mice, while also reducing the colony-forming unit (CFU) counts on joint tissues and implant surfaces [2]. |
| Synonyms | TBI 223 |
| Molecular Weight | 365.36 |
| Formula | C17H20FN3O5 |
| Cas No. | 2071265-08-0 |
| Smiles | FC1=C(N2CC3(C2)COC3)C=CC(=C1)N4C[C@H](CNC(OC)=O)OC4=O |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40.00 mg/mL (109.48 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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