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Sophoraflavanone G

Name: Sophoraflavanone G
Brand: TargetMol
SKU: T5S1000
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Vexibinol, Kushenol F) Copy Product Info

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Synonyms: Vexibinol, Kushenol F

Catalog No. T5S1000 Copy Product Info

Purity: 99.77%

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Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.

Cas No. 97938-30-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$32	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$209	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$519	-	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.77%

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
Targets & IC50	MDA-MB-231 cells:29.7 μM (IC50)
In vitro	Sophoraflavanone G (0-100 μM; 24 hours) reduces HL-60 cell viability in a dose-dependent manner and induces apoptosis by activating caspase-3 and caspase-9, downregulating Bcl-2 and Bcl-xL, upregulating Bax, and releasing cytochrome c from mitochondria to cytoplasm, thus promoting apoptosis via the mitochondrially-mediated intrinsic pathway [1]. Additionally, Sophoraflavanone G (0-40 μM; 24 hours) inhibits MDA-MB-231 cell viability with an IC50 of 29.7 μM in a concentration-dependent manner [2].
Synonyms	Vexibinol, Kushenol F

Chemical Properties

Molecular Weight	424.49
Formula	C₂₅H₂₈O₆
Cas No.	97938-30-2
Smiles	CC(C)=CC[C@H](Cc1c(O)cc(O)c2C(=O)C[C@H](Oc12)c1ccc(O)cc1O)C(C)=C
Relative Density.	1.266 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (341.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 10 mg/mL (23.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Saline: < 10 mg/mL (23.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Corn oil: < 10 mg/mL (23.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% (20% SBE-β-CD in Saline): < 10 mg/mL (23.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3558 mL	11.7788 mL	23.5577 mL	117.7884 mL
5 mM	0.4712 mL	2.3558 mL	4.7115 mL	23.5577 mL
10 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7788 mL
20 mM	0.1178 mL	0.5889 mL	1.1779 mL	5.8894 mL
50 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	1.1779 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc