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PD 169316

Name: PD 169316
Brand: TargetMol
SKU: T2432
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2432Cas No. 152121-53-4

PD 169316 is a potent, cell-permeable, and selective inhibitor of p38 MAP kinase.

PD 169316

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Purity: 98.65%

Catalog No. T2432Cas No. 152121-53-4

PD 169316 is a potent, cell-permeable, and selective inhibitor of p38 MAP kinase.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$48	In Stock	In Stock
10 mg	$79	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$226	In Stock	In Stock
100 mg	$397	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.65%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

PD 169316 AI Summary

PD 169316 exhibits a diverse range of bioactivities. It notably inhibits interleukin-1 (IL-1) synthesis in human monocytes with an IC50 of 50.0 nM and shows inhibitory activity against p38 MAP kinase with an IC50 of 89.0 nM. The compound also affects the thermal stability of several protein kinases involved in various signaling pathways, including AMPKA2, CAMK proteins, CDKs, GSK3B, JAK1~B, MEK2, ERKs, PAKs, and PLKs, indicating potential modulation of their activities. Additionally, PD 169316 demonstrates moderate antiplasmodial activity against strains of Plasmodium falciparum, with IC50 values ranging from 3162.28 nM to 6309.57 nM. It shows strong inhibitory activity in modulating Lamin A splicing with a potency of 4.5 nM and acts as an agonist for the NFkB signaling pathway at 12589.3 nM. Moreover, it inhibits APE1 with an IC50 of 15848.9 nM and TDP1 with potencies ranging from 15848.9 nM to 56234.1 nM. PD 169316 also inhibits 5-lipoxygenase with an IC50 of 8000.0 nM and demonstrates 16.87% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM, along with a minor antiviral effect against SARS-CoV-2 cytotoxicity in VERO-6 cells at 10 µM concentration. It reduces melanin synthesis by inhibiting tyrosinase in mouse B16F10 cells, showing an IC50 of 89.0 nM. Lastly, the compound exhibits cytotoxicity against human HepG2 cells with an IC50 of 50000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PD 169316 is a potent, cell-permeable, and selective inhibitor of p38 MAP kinase.
Targets&IC50	p38 MAPk:89 nM.

Chemical Properties

Molecular Weight	360.34
Formula	C₂₀H₁₃FN₄O₂
Cas No.	152121-53-4
Smiles	FC1=CC=C(C2=C(N=C(N2)C3=CC=C(N(=O)=O)C=C3)C=4C=CN=CC4)C=C1
Relative Density.	1.345 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 7.9 mg/mL (21.92 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7752 mL	13.8758 mL	27.7516 mL	138.7578 mL
5 mM	0.5550 mL	2.7752 mL	5.5503 mL	27.7516 mL
10 mM	0.2775 mL	1.3876 mL	2.7752 mL	13.8758 mL
20 mM	0.1388 mL	0.6938 mL	1.3876 mL	6.9379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc