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Irpagratinib

🥰Excellent
Catalog No. T79850Cas No. 2230974-62-4
Alias ABSK011, ABSK 011

Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer.

Irpagratinib

Irpagratinib

🥰Excellent
Purity: 99.38%
Catalog No. T79850Alias ABSK011, ABSK 011Cas No. 2230974-62-4
Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$92In StockIn Stock
5 mg$226In StockIn Stock
10 mg$363In StockIn Stock
25 mg$728In StockIn Stock
1 mL x 10 mM (in DMSO)$283In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.38%
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Product Introduction

Bioactivity
Description
Irpagratinib (ABSK011) is an orally active and highly effective FGFR4 antagonist with antitumor activity, inhibiting FGFR4 autophosphorylation and blocking FGFR4 signaling to downstream pathways. It is used in studies of gastrointestinal diseases and cancer.
Targets&IC50
FGFR4:< 10 nM
In vitro
Irpagratinib inhibits FGFR4 with IC50 < 10 nM and shows at least 50-fold selectivity against other FGFR kinases. Irpagratinib has the ability to irreversibly modify Cys552. [1]
In vivo
Oral Irpagratinib strongly inhibited the growth of subcutaneous xenograft tumors dependent on FGFR4 activity and induced their regression. [1]
SynonymsABSK011, ABSK 011
Chemical Properties
Molecular Weight570.59
FormulaC28H32F2N6O5
Cas No.2230974-62-4
SmilesN(C1=NC=2C(=NC(=CC2C=N1)C3=C(F)C(OC)=CC(OC)=C3F)N4CC(OC)(C)C4)[C@H]5[C@@H](NC(C=C)=O)CCOC5
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (140.21 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.78 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7526 mL8.7629 mL17.5257 mL87.6286 mL
5 mM0.3505 mL1.7526 mL3.5051 mL17.5257 mL
10 mM0.1753 mL0.8763 mL1.7526 mL8.7629 mL
20 mM0.0876 mL0.4381 mL0.8763 mL4.3814 mL
50 mM0.0351 mL0.1753 mL0.3505 mL1.7526 mL
100 mM0.0175 mL0.0876 mL0.1753 mL0.8763 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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