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DSP-4 hydrochloride

Name: DSP-4 hydrochloride
Brand: TargetMol
SKU: T13664
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13664Cas No. 40616-75-9

Alias Neurotoxin DSP 4 (hydrochloride)

DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC). is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats,

DSP-4 hydrochloride

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Purity: 99.9%

Catalog No. T13664Alias Neurotoxin DSP 4 (hydrochloride)Cas No. 40616-75-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$64	In Stock	In Stock
50 mg	$162	In Stock	In Stock
100 mg	$250	In Stock	In Stock
200 mg	$374	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

DSP-4 hydrochloride AI Summary

DSP-4 hydrochloride exhibits a wide range of bioactivities, including significant antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 10000.0 nM to 12589.25 nM after 72 hours using the SYBR green assay. It is also potent in inhibiting the proliferation of P. falciparum lines Dd2, 3D7, W2, 7G8, and D10. Additionally, DSP-4 hydrochloride demonstrates capabilities such as inducing genomic imprint erasure, acting as a general anesthetic, modulating Lamin A splicing, and inhibiting cell-membrane permeable IMPase. It is an effective inhibitor of Bloom's syndrome helicase (BLM) and exhibits activity against the Marburg Virus, besides inducing DNA re-replication in various cell types. Moreover, it inhibits norepinephrine reuptake at NET in rat brain cortical synaptosomes with an IC50 of 50.0 nM, and dopamine reuptake at DAT in rat brain striatal synaptosomes with an IC50 of 5870.0 nM, yielding a selectivity ratio of 117.4 for dopamine reuptake to norepinephrine reuptake inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus coeruleus (LC). is a highly selective neurotoxin and readily passes the blood-brain barrier with neurotoxic effects on noradrenergic neurons of adult and developing rats,
Synonyms	Neurotoxin DSP 4 (hydrochloride)

Chemical Properties

Molecular Weight	313.06
Formula	C₁₁H₁₆BrCl₂N
Cas No.	40616-75-9
Smiles	Cl.CCN(CCCl)Cc1ccccc1Br
Relative Density.	1.338g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (399.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1943 mL	15.9714 mL	31.9428 mL	159.7138 mL
5 mM	0.6389 mL	3.1943 mL	6.3886 mL	31.9428 mL
10 mM	0.3194 mL	1.5971 mL	3.1943 mL	15.9714 mL
20 mM	0.1597 mL	0.7986 mL	1.5971 mL	7.9857 mL
50 mM	0.0639 mL	0.3194 mL	0.6389 mL	3.1943 mL
100 mM	0.0319 mL	0.1597 mL	0.3194 mL	1.5971 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc