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Anti-GDF-6 Polyclonal Antibody (Synonyms: Growth/differentiation factor 6, Growth/differentiation factor 16, G...)
Catalog No. TMAB-00758 Copy Product Info
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Anti-GDF-6 Polyclonal Antibody is a Rabbit antibody targeting GDF-6. Anti-GDF-6 Polyclonal Antibody can be used in WB.
Anti-GDF-6 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-00758
Synonyms Growth/differentiation factor 6, Growth/differentiation factor 16, GDF-6, GDF6, GDF16, Bone morphogenetic protein 13 (BMP-13), BMP13
Anti-GDF-6 Polyclonal Antibody is a Rabbit antibody targeting GDF-6. Anti-GDF-6 Polyclonal Antibody can be used in WB.
Anti-GDF-6 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-GDF-6 Polyclonal Antibody is a Rabbit antibody targeting GDF-6. Anti-GDF-6 Polyclonal Antibody can be used in WB. |
| Synonyms | Growth/differentiation factor 6, Growth/differentiation factor 16, GDF-6, GDF6, GDF16, Bone morphogenetic protein 13 (BMP-13), BMP13 |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Cow,Horse,Rabbit) |
| Verified Activity | Sample: U251 (Human) Cell Lysate at 30 μg Primary: Anti-GDF6 (TMAB-00758) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 14 kDa Observed band size: 48 kDa  |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Growth/differentiation factors (GDFs) are members of the TGF superfamily (1,2). Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis (1). GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development (3). Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary (4). GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. (5). GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs (6). GDF-6 and GDF-7 are closely related to GDF-5 (6). GDF-8 has been shown to be a negative regulator of skeletal muscle mass (1). |
| Immunogen | KLH conjugated synthetic peptide: human GDF6 |
| Antigen Species | Human |
| Gene Name | GDF6 |
| Gene ID | |
| Protein Name | Growth/differentiation factor 6 |
| Uniprot ID | |
| Biology Area | Neurogenesis,Visual system,TGF |
| Function | GDF6 (Growth/differentiation factor 6) is expressed in hypertrophic chondrocytes during embryonic development of long bones and is required for normal formation of bones and joints in the limbs, skull, and axial skeleton. It plays a key role in establishing boundaries between skeletal elements during development. The functional form of GDF6 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains obtained by proteolytic processing of a biologically inactive precursor protein. |
| Molecular Weight | Theoretical: 14 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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