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Tiazofurin

🥰Excellent
Catalog No. T40686Cas No. 60084-10-8
Alias Riboxamide, NSC 286193

Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.

Tiazofurin

Tiazofurin

🥰Excellent
Purity: 99.91%
Catalog No. T40686Alias Riboxamide, NSC 286193Cas No. 60084-10-8
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35In StockIn Stock
5 mg$73In StockIn Stock
10 mg$123In StockIn Stock
25 mg$198In StockIn Stock
50 mg$297In StockIn Stock
1 mL x 10 mM (in DMSO)$74In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.91%
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Product Introduction

Bioactivity
Description
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.
SynonymsRiboxamide, NSC 286193
Chemical Properties
Molecular Weight260.27
FormulaC9H12N2O5S
Cas No.60084-10-8
SmilesNC(=O)c1csc(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Relative Density.1.648g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (192.11 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8422 mL19.2108 mL38.4216 mL192.1082 mL
5 mM0.7684 mL3.8422 mL7.6843 mL38.4216 mL
10 mM0.3842 mL1.9211 mL3.8422 mL19.2108 mL
20 mM0.1921 mL0.9605 mL1.9211 mL9.6054 mL
50 mM0.0768 mL0.3842 mL0.7684 mL3.8422 mL
100 mM0.0384 mL0.1921 mL0.3842 mL1.9211 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TiazofurinOrthopoxvirusNucleoside Antimetabolite/AnalogNSC-286193NSC286193InhibitorinhibitIMPDH
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