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Tiazofurin

Name: Tiazofurin
Brand: TargetMol
SKU: T40686
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40686Cas No. 60084-10-8

Alias Riboxamide, NSC 286193

Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.

Tiazofurin

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Purity: 99.91%

Catalog No. T40686Alias Riboxamide, NSC 286193Cas No. 60084-10-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$297	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Tiazofurin AI Summary

Tiazofurin demonstrates significant antiproliferative and cytotoxic activity against a range of human cancer cell lines, including K562, HL60, HT-29, MCF7, HeLa, and MRC5 cells, with IC50 values ranging from 40.0 nM to 9320.0 nM. It specifically shows potent cytotoxicity against Jurkat T cells (IC50 = 40.0 nM) and HT29 cells (IC50 = 890.0 nM), with the least effect on Raji cells (IC50 = 16,060.0 nM). The compound exhibits multiple mechanisms of action, including the inhibition of IMP dehydrogenase (IMPDH) types I and II with IC50 values around 94.0 nM to 101.0 nM, and Ki values at 100.0 nM. Furthermore, it influences guanine nucleotide pools in various cancer cell lines and induces cell cycle arrest at different phases and apoptosis markers in K562 cells, leading to benzidine positive differentiation at higher concentrations (80.0% at 15 uM). In vivo studies show its impact on mouse models, including increased lifespan in leukemia models, dose-dependent weight effects, and specific liver-related toxicities. The compound also demonstrates antiviral activities against parainfluenza and herpes simplex virus type 2. Overall, Tiazofurin exhibits a broad spectrum of bioactivities with potential applications in anti-cancer therapies, subject to further toxicity and efficacy evaluations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.
Synonyms	Riboxamide, NSC 286193

Chemical Properties

Molecular Weight	260.27
Formula	C₉H₁₂N₂O₅S
Cas No.	60084-10-8
Smiles	NC(=O)c1csc(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Relative Density.	1.648g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (192.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8422 mL	19.2108 mL	38.4216 mL	192.1082 mL
5 mM	0.7684 mL	3.8422 mL	7.6843 mL	38.4216 mL
10 mM	0.3842 mL	1.9211 mL	3.8422 mL	19.2108 mL
20 mM	0.1921 mL	0.9605 mL	1.9211 mL	9.6054 mL
50 mM	0.0768 mL	0.3842 mL	0.7684 mL	3.8422 mL
100 mM	0.0384 mL	0.1921 mL	0.3842 mL	1.9211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc