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Anti-alpha 2 Macroglobulin Polyclonal Antibody

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Catalog No. TMAB-02457

Anti-alpha 2 Macroglobulin Polyclonal Antibody is a Rabbit antibody targeting alpha 2 Macroglobulin. Anti-alpha 2 Macroglobulin Polyclonal Antibody can be used in WB.

Anti-alpha 2 Macroglobulin Polyclonal Antibody

Anti-alpha 2 Macroglobulin Polyclonal Antibody

😃Good
Catalog No. TMAB-02457
Anti-alpha 2 Macroglobulin Polyclonal Antibody is a Rabbit antibody targeting alpha 2 Macroglobulin. Anti-alpha 2 Macroglobulin Polyclonal Antibody can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3737-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-alpha 2 Macroglobulin Polyclonal Antibody is a Rabbit antibody targeting alpha 2 Macroglobulin. Anti-alpha 2 Macroglobulin Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Human (predicted:Mouse,Rat)
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted
Tissue SpecificitySecreted in plasma
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundAlpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human alpha 2 Macroglobulin
Antigen Species
Human
Gene Name
A2M
Gene ID
2
Protein Name
alpha-2-macroglobulin
Uniprot ID
P01023
Function
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Chemical Properties
Molecular WeightTheoretical: 160 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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