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D-(+)-Trehalose

Name: D-(+)-Trehalose
Brand: TargetMol
SKU: T2O2798
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2O2798Cas No. 99-20-7

Alias Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous

D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

D-(+)-Trehalose

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Purity: 99.82%

Catalog No. T2O2798Alias Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose AnhydrousCas No. 99-20-7

D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$81	In Stock	In Stock
1 g	$118	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.82%

Color:White

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Product Introduction

D-(+)-Trehalose AI Summary

D-(+)-Trehalose demonstrates a multifaceted bioactivity profile, including potential neuroprotective effects in R6/2 transgenic mice, where it significantly increased the mean survival time to 94.5 days at a 1% oral concentration, albeit with a 25.0% body weight loss after 12 weeks, indicating some toxicity concerns. The compound notably inhibits amyloid beta-40 and amyloid beta (1 to 42) aggregation across various structural forms (unordered, beta-turns, beta-sheets, alpha-helix) and concentrations, as well as reduces amyloid beta-40-induced cell death in C57BL/6 mouse primary cortical neurons. Additionally, D-(+)-Trehalose shows inhibitory activity against various T6PP enzymes from different organisms, with the highest activity against Brugia malayi T6PP. It exhibits antiviral properties against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in Caco-2 and VERO-6 cells, with moderate inhibition of SARS-CoV-2 3CL-Pro protease at 20µM. The compound also demonstrates a binding affinity to Mycobacterium tuberculosis LpqY, with a dissociation constant (Kd) of 36100.0 nM, and shows weak inhibitory activity against human HDAC6. These diverse bioactivities suggest that D-(+)-Trehalose could be a promising candidate for further research and development in various therapeutic areas..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(+)-Trehalose (Mycose) can inhibit the decomposition of collagen, so it can be used to improve osteoporosis.
Synonyms	Trehalose, Mycose, Ergot Sugar, D-Trehalose, D-(+)-Trehalose Anhydrous

Chemical Properties

Molecular Weight	342.30
Formula	C₁₂H₂₂O₁₁
Cas No.	99-20-7
Smiles	O([C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Relative Density.	1.76 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 247.5 mg/mL (723.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9214 mL	14.6071 mL	29.2141 mL	146.0707 mL
5 mM	0.5843 mL	2.9214 mL	5.8428 mL	29.2141 mL
10 mM	0.2921 mL	1.4607 mL	2.9214 mL	14.6071 mL
20 mM	0.1461 mL	0.7304 mL	1.4607 mL	7.3035 mL
50 mM	0.0584 mL	0.2921 mL	0.5843 mL	2.9214 mL
100 mM	0.0292 mL	0.1461 mL	0.2921 mL	1.4607 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc