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Bimatoprost

Name: Bimatoprost
Brand: TargetMol
SKU: T2538
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2538Cas No. 155206-00-1

Alias AGN 192024

Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.

Bimatoprost

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Purity: 99.65%

Catalog No. T2538Alias AGN 192024Cas No. 155206-00-1

Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$43	In Stock	In Stock
10 mg	$73	In Stock	In Stock
25 mg	$136	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$413	In Stock	In Stock
200 mg	$607	-	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.65%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
In vitro	Bimatoprost is an effective prostaglandin FP receptor agonist, capable of directly inducing a robust and rapid return of calcium ions to baseline levels. It directly activates FP prostaglandin receptors in rats, mice, and humans.
In vivo	Bimatoprost displaces [3H] prostaglandin F (2alpha) binding to FP receptors with a Ki of 6.31 μM. It rapidly mobilizes intracellular calcium in 3T3 mouse fibroblasts expressing FP receptors (EC50: 2.2 μM) and human embryonic kidney cells with human FP receptors (EC50: 2.94 μM). Bimatoprost upregulates Cyr61 expression in feline irises and mildly stimulates aqueous humor outflow rate, increasing it by 13% during the day and 14% at night, while reducing tonographic outflow by 26%, thereby lowering intraocular pressure.
Synonyms	AGN 192024

Chemical Properties

Molecular Weight	415.57
Formula	C₂₅H₃₇NO₄
Cas No.	155206-00-1
Smiles	CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc1ccccc1
Relative Density.	1.145 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (601.58 mM), Sonication is recommended.

Ethanol: 77 mg/mL (185.29 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4063 mL	12.0317 mL	24.0633 mL	120.3167 mL
5 mM	0.4813 mL	2.4063 mL	4.8127 mL	24.0633 mL
10 mM	0.2406 mL	1.2032 mL	2.4063 mL	12.0317 mL
20 mM	0.1203 mL	0.6016 mL	1.2032 mL	6.0158 mL
50 mM	0.0481 mL	0.2406 mL	0.4813 mL	2.4063 mL
100 mM	0.0241 mL	0.1203 mL	0.2406 mL	1.2032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc