Anti-SMAD4 Antibody (1D720)

Name: Anti-SMAD4 Antibody (1D720)
Brand: TargetMol
SKU: TMAB-01741
Rating: 4.5 (1 reviews)

(Synonyms: SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4) Copy Product Info

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Synonyms: SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4

Catalog No. TMAB-01741 Copy Product Info

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Anti-SMAD4 Antibody (1D720) is a Rabbit antibody targeting SMAD4. Anti-SMAD4 Antibody (1D720) can be used in IF,IHC-Fr,IHC-P,WB.

Anti-SMAD4 Antibody
(1D720)

Pack Size	Price	USA Stock	Global Stock	Quantity
50 μL	$273	7-10 days	7-10 days
100 μL	$487	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-SMAD4 Antibody (1D720) is a Rabbit antibody targeting SMAD4. Anti-SMAD4 Antibody (1D720) can be used in IF,IHC-Fr,IHC-P,WB.
Synonyms	SMAD4, SMAD Family Member 4, SMAD 4, Mothers Against DPP Homolog 4, Mothers Against Decapentaplegic Homolog 4, MADH4, MAD Homolog 4, hSMAD4, DPC4, Deletion Target in Pancreatic Carcinoma 4
Ig Type	IgG
Clone	1D720
Reactivity	Human,Mouse,Rat

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
Antibody Type	Monoclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation in response to TGF-beta.
Construction	Recombinant Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Smad 4 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided in 3 subgroups based on their structure and functions; pathway-restricted, common mediator and inhibitory Smad. Smad 4 is the common Smad (co-Smad). Previously identified as the tumor suppressor DPC4 (deleted in pancreatic carcinoma, locus 4), Smad 4 is functionally distinct among the Smad family, and is required for the assembly and transcriptional activation of diverse, Smad-DNA complexes. In contrast to the R-Smads, Smad 4 is not regulated by phosphorylation, but acts as a common mediator of TGF-Beta, activin, and bone morphogenetic protein signaling responses. Smad 4 is frequently inactivated in pancreatic, biliary and colorectal tumors.

Antigen Details

Immunogen	A synthesized peptide: human SMAD4
Antigen Species	Human
Gene Name	SMAD4
Gene ID	4089
Protein Name	Mothers against decapentaplegic homolog 4
Uniprot ID	Q13485
Biology Area	Response to hypoxia,Tumor suppressors,Apoptosis,Transcription factors/regulators,Transcription factors,Endothelium,SMADs,Hypoxia,SMADs,Cytoplasmic
Function	Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.