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Ethamsylate

Name: Ethamsylate
Brand: TargetMol
SKU: T0002
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0002Cas No. 2624-44-4

Alias Etamsylate, Dicynene, Cyclonamine, Aglumin

Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.

Ethamsylate

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Purity: 98.55%

Catalog No. T0002Alias Etamsylate, Dicynene, Cyclonamine, AgluminCas No. 2624-44-4

Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.55%

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COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.
In vitro	High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.
In vivo	High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.
Synonyms	Etamsylate, Dicynene, Cyclonamine, Aglumin

Chemical Properties

Molecular Weight	263.31
Formula	C₁₀H₁₇NO₅S
Cas No.	2624-44-4
Smiles	Oc1cc(c(O)cc1)S(=O)(=O)O.C(NCC)C
Relative Density.	1.3441 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (189.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7978 mL	18.9890 mL	37.9780 mL	189.8902 mL
5 mM	0.7596 mL	3.7978 mL	7.5956 mL	37.9780 mL
10 mM	0.3798 mL	1.8989 mL	3.7978 mL	18.9890 mL
20 mM	0.1899 mL	0.9495 mL	1.8989 mL	9.4945 mL
50 mM	0.0760 mL	0.3798 mL	0.7596 mL	3.7978 mL
100 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc