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Ethamsylate

Name: Ethamsylate
Brand: TargetMol
SKU: T0002
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0002Cas No. 2624-44-4

Alias Etamsylate, Dicynene, Cyclonamine, Aglumin

Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.

Ethamsylate

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Purity: 98.55%

Catalog No. T0002Alias Etamsylate, Dicynene, Cyclonamine, AgluminCas No. 2624-44-4

Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.55%

Appearance:Solid

Color:White

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COA LCMS HNMR HPLC

Product Introduction

Ethamsylate AI Summary

Ethamsylate demonstrates diverse bioactivities across a range of assays. It serves as a modulator of Lamin A splicing with a potency of 141.3 nM and exhibits activities as a small molecule agonist and antagonist for the Hypoxia Response Element signaling pathway with a potency of 398.1 nM. Moreover, it inhibits HSD17B4 and Histone Lysine Methyltransferase G9a with potencies of 10000.0 nM. The compound further shows inhibition of HPGD at 14125.4 nM and HADH2 at 251.2 nM. In terms of antiviral properties, Ethamsylate inhibits ADP-induced platelet aggregation in human plasma with an IC50 of 46220.0 nM. It has been observed to reduce cell viability in Vero E6 cells infected with SARS-CoV-2, showing lower activity compared to the control arbidol with an inhibition index of 0.6843 after 72 hours of infection. Additionally, at 10 µM concentration, it inhibits cytotoxicity in Caco-2 cells by 26.85% after 48 hours and inhibits SARS-CoV-2 3CL-Pro protease by 2.17% at a concentration of 20 µM. The compound also reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells after 48 hours of exposure to the virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethamsylate (Dicynene) usually is used as a hemostatic drug, which increases capillary endothelial resistance and platelet adhesion, and inhibits biosynthesis and action of prostaglandins.
In vitro	High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.
In vivo	High concentrations of Ethamsylate were able to remove superoxide radicals. In the presence of Ethamsylate, arachidonic acid, thromboxane A2, collagen, and the calcium carrier A23187 promoted the induction of human platelet aggregation and the release of ATP.Ethamsylate inhibited the production of prostaglandins in the microsomes of pregnant women's uterine myometrium at an IC50 of 0.5 mM. Ethamsylate was highly effective in inhibiting hydroxyl radicals (OH.) at concentrations of 0.1-10 μM.
Synonyms	Etamsylate, Dicynene, Cyclonamine, Aglumin

Chemical Properties

Molecular Weight	263.31
Formula	C₁₀H₁₇NO₅S
Cas No.	2624-44-4
Smiles	Oc1cc(c(O)cc1)S(=O)(=O)O.C(NCC)C
Relative Density.	1.3441 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (189.89 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (9.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7978 mL	18.9890 mL	37.9780 mL	189.8902 mL
5 mM	0.7596 mL	3.7978 mL	7.5956 mL	37.9780 mL
10 mM	0.3798 mL	1.8989 mL	3.7978 mL	18.9890 mL
20 mM	0.1899 mL	0.9495 mL	1.8989 mL	9.4945 mL
50 mM	0.0760 mL	0.3798 mL	0.7596 mL	3.7978 mL
100 mM	0.0380 mL	0.1899 mL	0.3798 mL	1.8989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc