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BQ-123

Name: BQ-123
Brand: TargetMol
SKU: T6792
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6792Cas No. 136553-81-6

Alias BQ123

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

BQ-123

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Purity: 99.22%

Catalog No. T6792Alias BQ123Cas No. 136553-81-6

BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	In Stock	In Stock
5 mg	$213	In Stock	In Stock
10 mg	$347	In Stock	In Stock
25 mg	$577	In Stock	In Stock
50 mg	$823	In Stock	In Stock
100 mg	$1,090	-	In Stock
1 mL x 10 mM (in DMSO)	$288	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.22%

Resource Download

COA HNMR HPLC MS

Product Introduction

Bioactivity

Description	BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.
Targets&IC50	ETA receptor:7.3 nM
In vitro	In porcine aortic vascular smooth muscle cells, BQ-123 selectively inhibits ETA-mediated contraction. [1] In rat vascular smooth muscle cells, BQ-123 inhibits endothelin-1-induced phosphoinositide breakdown and DNA synthesis. [2]
In vivo	In rats, BQ-123 (1 mg/kg, i.v.) ameliorates myocardial ischemic-reperfusion injury. [3] In rats with pentylenetetrazole (PTZ)-induced tonic-clonic seizures, BQ-123 (3 mg/kg, i.v.) potently impedes the formation and spread of seizure. [4] In pregnant C57BL/6 mice, BQ-123 (6.7 mg/kg, i.p.) prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. [5]
Synonyms	BQ123

Chemical Properties

Molecular Weight	610.7
Formula	C₃₁H₄₂N₆O₇
Cas No.	136553-81-6
Smiles	[H][C@@]12CCCN1C(=O)[C@@]([H])(CC(O)=O)NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C
Relative Density.	1.33 g/cm3 (Predicted)
Color	White
Appearance	Solid
Sequence	Cyclo(d-Asp-Pro-d-Val-Leu-d-Trp)
Sequence Short	Cyclo(d-DP-d-VL-d-W)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 12 mg/mL (19.65 mM), Sonication is recommended.

DMSO: 93 mg/mL (152.28 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (8.19 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6375 mL	8.1873 mL	16.3747 mL	81.8733 mL
5 mM	0.3275 mL	1.6375 mL	3.2749 mL	16.3747 mL
10 mM	0.1637 mL	0.8187 mL	1.6375 mL	8.1873 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.0819 mL	0.4094 mL	0.8187 mL	4.0937 mL
50 mM	0.0327 mL	0.1637 mL	0.3275 mL	1.6375 mL
100 mM	0.0164 mL	0.0819 mL	0.1637 mL	0.8187 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc