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Ginsenoside F2

Name: Ginsenoside F2
Brand: TargetMol
SKU: T3916
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3916Cas No. 62025-49-4

Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction.

Ginsenoside F2

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Purity: 99.3%

Catalog No. T3916Cas No. 62025-49-4

Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$63	In Stock	In Stock
10 mg	$90	In Stock	In Stock
25 mg	$147	In Stock	In Stock
50 mg	$215	In Stock	In Stock
100 mg	$318	In Stock	In Stock
500 mg	$773	-	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.3%

Color:White

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COA HPLC HNMR

Product Introduction

Ginsenoside F2 AI Summary

Ginsenoside F2 shows no significant inhibitory activity against human DNA topoisomerase 1 and 2, with IC50 values exceeding 250,000.0 nM in both assays. However, it exhibits notable bioactivity in inhibiting cell proliferation. In human U251 cells, Ginsenoside F2 achieved a 64.58% inhibition of cell viability at a concentration of 100 uM after 72 hours. Additionally, in rat C6 cells, it demonstrated an even higher inhibition rate of 117.12% under the same conditions, indicating its potential anti-proliferative effects on these specific cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Ginsenoside F2 has antiproliferative activity against breast cancer stem cells (CSCs). It induces apoptosis in breast CSCs by activating the intrinsic apoptotic pathway and mitochondrial dysfunction.

Chemical Properties

Molecular Weight	785.01
Formula	C₄₂H₇₂O₁₃
Cas No.	62025-49-4
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O[C@]4([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@]3([H])CC[C@@]21C)[C@](C)(CCC=C(C)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.303 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (152.86 mM), Sonication is recommended.

H2O: 2.08 mg/mL (2.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2739 mL	6.3693 mL	12.7387 mL	63.6935 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2548 mL	1.2739 mL	2.5477 mL	12.7387 mL
10 mM	0.1274 mL	0.6369 mL	1.2739 mL	6.3693 mL
20 mM	0.0637 mL	0.3185 mL	0.6369 mL	3.1847 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2739 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.6369 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc