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VAS2870

Name: VAS2870
Brand: TargetMol
SKU: T4359
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4359Cas No. 722456-31-7

VAS2870 is an inhibitor of NADPH oxidase (NOX).

VAS2870

🥰Excellent

Purity: 99.74%

Catalog No. T4359Cas No. 722456-31-7

VAS2870 is an inhibitor of NADPH oxidase (NOX).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$52	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$189	In Stock	In Stock
50 mg	$345	In Stock	In Stock
100 mg	$516	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

VAS2870 is an inhibitor of NADPH oxidase (NOX).

In vitro

VAS2870 effectively inhibits the growth and proliferation of FaO rat hepatoma cells and various human hepatocellular carcinoma (HCC) cell lines, while also enhancing TGF-b-mediated apoptosis in these cells. It suppresses the activation of NADPH oxidase and the production of intracellular ROS induced by PDGF-BB, without affecting DNA synthesis. Preincubation with VAS2870 at concentrations of 10 and 20 μM completely prevents PDGF-mediated NADPH oxidase activation and ROS production, although it does not interfere with PDGF-induced cell cycle progression. However, VAS2870 does effectively eliminate PDGF-dependent chemotaxis of VSMC, achieving 100% inhibition at 10 μM. Additionally, VAS2870 dose-dependently reduces autocrine cell number increases in FaO rat hepatoma cells, and at 25 mM, it almost completely blocks ROS production and thymidine incorporation.

Chemical Properties

Molecular Weight	360.39
Formula	C₁₈H₁₂N₆OS
Cas No.	722456-31-7
Smiles	C(c1ccccc1)n1nnc2c(Sc3nc4ccccc4o3)ncnc12
Relative Density.	1.53 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (231.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7748 mL	13.8739 mL	27.7477 mL	138.7386 mL
5 mM	0.5550 mL	2.7748 mL	5.5495 mL	27.7477 mL
10 mM	0.2775 mL	1.3874 mL	2.7748 mL	13.8739 mL
20 mM	0.1387 mL	0.6937 mL	1.3874 mL	6.9369 mL
50 mM	0.0555 mL	0.2775 mL	0.5550 mL	2.7748 mL
100 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3874 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc