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Harpagoside

Name: Harpagoside
Brand: TargetMol
SKU: T6S2023
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2023Cas No. 19210-12-9

1. Harpagoside has anti-inflammatory activity. 2. Harpagoside at 3 mM concentration, shows moderate inhibition of seed germination. 3. Harpagoside can inhibit lipopolysaccharide-induced mRNA levels and protein expression of cyclooxygenase-2 and inducible nitric oxide in HepG2 cells.

Harpagoside

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Purity: 99.99%

Catalog No. T6S2023Cas No. 19210-12-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$58	In Stock	In Stock
10 mg	$91	In Stock	In Stock
20 mg	$148	In Stock	In Stock
25 mg	$165	In Stock	In Stock
50 mg	$246	In Stock	In Stock
100 mg	$371	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Harpagoside AI Summary

Harpagoside demonstrates a broad spectrum of bioactivities. It exhibits neuroprotective properties in Sprague-Dawley rat cortical neurons by significantly reducing glutamate-induced LDH release, with efficacy percentages of 44.7%, 38.5%, and 38.2% at concentrations of 10 µM, 1 µM, and 0.1 µM, respectively. The compound additionally shows potential antiviral activity against HCV expressing E1E2 glycoprotein using a Vpr-deficient HIV vector in human Huh7 cells, where inhibition percentages range from -41.7% to 17.1%. Anti-inflammatory effects are noted in HUVEC cells by inhibiting TNF-alpha-induced E-selectin expression, with an IC50 of 88200 nM. Further characterization reveals inhibitory activities against Schistosoma mansoni peroxiredoxins (3548.1 nM), histone lysine methyltransferase G9a (17782.8 nM), and HP1-beta chromodomain interactions with methylated histone tails (89125.1 nM). Harpagoside also induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 115.8 nM. In terms of cytotoxicity, the compound demonstrates greater than 90.0% activity against MC3T3-E1 cells and supports cell survival in mouse osteoclasts with survival rates exceeding 85.0%. It affects calcium and potassium levels in OVX-induced bone loss ICR mouse models, increasing serum calcium concentration and slightly decreasing potassium levels at lower doses. The compound also influences alkaline phosphatase activity and impacts TRAP activity, osteocalcin, and C-terminal telopeptide levels at varying doses, highlighting its role in bone metabolism. Furthermore, it shows less than 50% inhibition of COX2 synthesis in pig skin assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	494.49
Formula	C₂₄H₃₀O₁₁
Cas No.	19210-12-9
Smiles	C[C@@]1(C[C@@H](O)[C@]2(O)C=CO[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]12)OC(=O)\C=C\c1ccccc1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 90 mg/mL (182.01 mM), Sonication is recommended.

Pyridine, Methanol, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0223 mL	10.1114 mL	20.2229 mL	101.1143 mL
5 mM	0.4045 mL	2.0223 mL	4.0446 mL	20.2229 mL
10 mM	0.2022 mL	1.0111 mL	2.0223 mL	10.1114 mL
20 mM	0.1011 mL	0.5056 mL	1.0111 mL	5.0557 mL
50 mM	0.0404 mL	0.2022 mL	0.4045 mL	2.0223 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc