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Florfenicol

Name: Florfenicol
Brand: TargetMol
SKU: T0454L
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0454LCas No. 73231-34-2

Alias SCH-25298, (-)-Florfenicol

Florfenicol (SCH-25298), a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Haemophilus somnus, and Pasteurella multocida, for therapy of bovine interdigital phlegmon (foot rot, infectious pododermatitis, acute interdigital necrobacillosis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. This compound is also used in aquaculture and is approved for use in the United States for the therapy of enteric septicemia in catfish.

Florfenicol

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Purity: 99.33%

Catalog No. T0454LAlias SCH-25298, (-)-FlorfenicolCas No. 73231-34-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$47	-	In Stock
1 g	$68	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Florfenicol (SCH-25298), a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Haemophilus somnus, and Pasteurella multocida, for therapy of bovine interdigital phlegmon (foot rot, infectious pododermatitis, acute interdigital necrobacillosis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. This compound is also used in aquaculture and is approved for use in the United States for the therapy of enteric septicemia in catfish.
In vitro	Florfenicol is found to stimulate algal growth at concentrations of 0.5, 1.0 and 2.0 mg/L, and significantly inhibit algal growth at >2.0 mg/L.
In vivo	Florfenicol administers at doses of 15 and 20 mg FFC kg(-1) bw per days for 10 days significantly reduces mortality associated with francisellosis in Nile tilapia.
Synonyms	SCH-25298, (-)-Florfenicol

Chemical Properties

Molecular Weight	358.21
Formula	C₁₂H₁₄Cl₂FNO₄S
Cas No.	73231-34-2
Smiles	[C@@H]([C@H](NC(C(Cl)Cl)=O)CF)(O)C1=CC=C(S(C)(=O)=O)C=C1
Relative Density.	1.451 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (139.58 mM), Sonication is recommended.

Ethanol: 8 mg/mL (22.33 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7917 mL	13.9583 mL	27.9166 mL	139.5829 mL
5 mM	0.5583 mL	2.7917 mL	5.5833 mL	27.9166 mL
10 mM	0.2792 mL	1.3958 mL	2.7917 mL	13.9583 mL
20 mM	0.1396 mL	0.6979 mL	1.3958 mL	6.9791 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0558 mL	0.2792 mL	0.5583 mL	2.7917 mL
100 mM	0.0279 mL	0.1396 mL	0.2792 mL	1.3958 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc