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SR8278

Name: SR8278
Brand: TargetMol
SKU: T7837
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7837Cas No. 1254944-66-5

SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112

SR8278

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Purity: 99.73%

Catalog No. T7837Cas No. 1254944-66-5

SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$318	In Stock
50 mg	$460	In Stock
100 mg	$676	In Stock
200 mg	$962	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Batch Information

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Purity:99.73%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112
In vitro	SR8278 stimulates the expression of two REV-ERBα target genes involved in the regulation of glucose production, glucose 6-phosphatase and phosphoenolpyruvate carboxykinase, in liver cells[1]

Chemical Properties

Molecular Weight	361.48
Formula	C₁₈H₁₉NO₃S₂
Cas No.	1254944-66-5
Smiles	CCOC(=O)C1Cc2ccccc2CN1C(=O)c1ccc(SC)s1
Relative Density.	1.32 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (138.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7664 mL	13.8320 mL	27.6640 mL	138.3202 mL
5 mM	0.5533 mL	2.7664 mL	5.5328 mL	27.6640 mL
10 mM	0.2766 mL	1.3832 mL	2.7664 mL	13.8320 mL
20 mM	0.1383 mL	0.6916 mL	1.3832 mL	6.9160 mL
50 mM	0.0553 mL	0.2766 mL	0.5533 mL	2.7664 mL
100 mM	0.0277 mL	0.1383 mL	0.2766 mL	1.3832 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc