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Anti-Endoglin/CD105 Antibody-Biotin (5X880)
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Catalog No. TMAY-00357B
Alias S-endoglin, endoglin, Endo, CD105, AI662476, AI528660
Anti-Endoglin/CD105 Antibody-Biotin (5X880) is a Biotin-conjugated Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-Biotin (5X880) can be used in ELISA.
Anti-Endoglin/CD105 Antibody-Biotin (5X880)
Anti-Endoglin/CD105 Antibody-Biotin (5X880)
😃Good
Catalog No. TMAY-00357BAlias S-endoglin, endoglin, Endo, CD105, AI662476, AI528660
Anti-Endoglin/CD105 Antibody-Biotin (5X880) is a Biotin-conjugated Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-Biotin (5X880) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $292 | 7-10 days |
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Chemical Properties
| Description | Anti-Endoglin/CD105 Antibody-Biotin (5X880) is a Biotin-conjugated Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-Biotin (5X880) can be used in ELISA. |
| Alias | S-endoglin, endoglin, Endo, CD105, AI662476, AI528660 |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 5X880 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh CD105; TMPY-01384; Met 1-Gly 586; NP_001108225.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| Conjucates | Biotin |
| Others Formats | Unconjugated/FITC/HRP |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD105 protein (TMPY-01384) |
| Antigen Species | Human |
| Biology Area | Hemangioblast Markers, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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