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Desfesoterodine

Name: Desfesoterodine
Brand: TargetMol
SKU: T6364
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6364Cas No. 207679-81-0

Alias PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl Tolterodine

Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

Desfesoterodine

🥰Excellent

Purity: 99.77%

Catalog No. T6364Alias PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl TolterodineCas No. 207679-81-0

Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$60	-	In Stock
5 mg	$147	-	In Stock
10 mg	$228	-	In Stock
25 mg	$392	-	In Stock
50 mg	$578	-	In Stock
100 mg	$833	-	In Stock
500 mg	$1,690	-	In Stock
1 mL x 10 mM (in DMSO)	$162	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.77%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Desfesoterodine (5-HMT) is a new muscarinic receptor antagonist with Kb of 0.84 nM.
Targets&IC50	mAChR:0.84 nM(Kb)
In vitro	Desfesoterodine is a major pharmacologically active metabolite of tolterodine. Desfesoterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. Desfesoterodine antagotizes muscarinic receptors with a pA2 of 9.1. Desfesoterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. [1] Desfesoterodine has a similar pharmacological profile with tolterodine. [2] Intravenous infusion of Desfesoterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure. [3]
In vivo	Desfesoterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. Desfesoterodine is three times more potent at the urinary bladder compared to the salivary gland. [1]
Synonyms	PNU-200577, 5-hydroxymethyl Tolterodine, 5-HMT, 5-HM, (R)-5-Hydroxymethyl Tolterodine

Chemical Properties

Molecular Weight	341.49
Formula	C₂₂H₃₁NO₂
Cas No.	207679-81-0
Smiles	CC(C)N(CC[C@H](c1ccccc1)c1cc(CO)ccc1O)C(C)C
Relative Density.	1.060 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 63 mg/mL (184.49 mM), Sonication is recommended.

DMSO: 65 mg/mL (190.34 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9283 mL	14.6417 mL	29.2834 mL	146.4172 mL
5 mM	0.5857 mL	2.9283 mL	5.8567 mL	29.2834 mL
10 mM	0.2928 mL	1.4642 mL	2.9283 mL	14.6417 mL
20 mM	0.1464 mL	0.7321 mL	1.4642 mL	7.3209 mL
50 mM	0.0586 mL	0.2928 mL	0.5857 mL	2.9283 mL
100 mM	0.0293 mL	0.1464 mL	0.2928 mL	1.4642 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc