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Pinoresinol dimethyl ether

Name: Pinoresinol dimethyl ether
Brand: TargetMol
SKU: T2S0531
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S0531Cas No. 29106-36-3

Alias (+)-Eudesmin

Pinoresinol dimethyl ether is a nonphenolic furan lignan isolated from the stem bark of Magnolia kobus with neurological activity. It stimulates upstream MAPK, PKC and PKA pathways and induces neural protrusion growth in PC12 cells.

Pinoresinol dimethyl ether

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Purity: 99.75%

Catalog No. T2S0531Alias (+)-EudesminCas No. 29106-36-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$98	In Stock	In Stock
25 mg	$162	In Stock	In Stock
50 mg	$238	In Stock	In Stock
100 mg	$357	-	In Stock
1 mL x 10 mM (in DMSO)	$76	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Pinoresinol dimethyl ether AI Summary

Pinoresinol dimethyl ether exhibits a range of biological activities. It shows cytotoxicity against human PANC1 cells in a nutrient-deprived medium after 24 hours, with an effective concentration greater than 100.0 µM. Additionally, it demonstrates cytotoxic effects on various cell lines, including mouse B16-BL6, LLC, colon 26-L5, and human A549, HeLa, and HT1080 cells after 72 hours as determined by MTT assay, with an IC50 value greater than 100,000.0 nM, indicating low cytotoxicity at the concentrations tested. The compound also inhibits nitric oxide production in LPS-stimulated mouse BV2 cells, with an IC50 of 30,000.0 nM, and in LPS-stimulated mouse RAW264.7 cells, with an IC50 greater than 50,000.0 nM. Furthermore, Pinoresinol dimethyl ether shows antialgal activity against Selenastrum capricornutum, Pseudanabaena sp. LW397, and Planktothrix agardhii at 100.0 µM and against Oscillatoria perornata at 10.0 µM. It also exhibits antifungal activity against Phomopsis obscurans, with more than 80.0% inhibition at 50 µM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pinoresinol dimethyl ether is a nonphenolic furan lignan isolated from the stem bark of Magnolia kobus with neurological activity. It stimulates upstream MAPK, PKC and PKA pathways and induces neural protrusion growth in PC12 cells.
Synonyms	(+)-Eudesmin

Chemical Properties

Molecular Weight	386.44
Formula	C₂₂H₂₆O₆
Cas No.	29106-36-3
Smiles	[H][C@]12CO[C@H](c3ccc(OC)c(OC)c3)[C@@]1([H])CO[C@@H]2c1ccc(OC)c(OC)c1
Relative Density.	1.173 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (646.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5877 mL	12.9386 mL	25.8772 mL	129.3862 mL
5 mM	0.5175 mL	2.5877 mL	5.1754 mL	25.8772 mL
10 mM	0.2588 mL	1.2939 mL	2.5877 mL	12.9386 mL
20 mM	0.1294 mL	0.6469 mL	1.2939 mL	6.4693 mL
50 mM	0.0518 mL	0.2588 mL	0.5175 mL	2.5877 mL
100 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2939 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc