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Alsevalimab
(Synonyms: FPA-150, FPA150, Anti-B7-H4 antibody) Copy Product Info
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Synonyms: FPA-150, FPA150, Anti-B7-H4 antibody
Catalog No. T78287 Copy Product Info
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Alsevalimab (FPA-150) is a humanized monoclonal antibody that targets B7-H4. Alsevalimab specifically binds to B7-H4 on the surface of tumor and immune cells, blocking its inhibitory signals on T-cell activation, reversing the immunosuppressive state of the tumor microenvironment, and activating the proliferation and tumor-killing functions of effector T cells. Alsevalimab also mediates ADCC effects, synergistically enhancing antitumor immunity. Alsevalimab is suitable for use in studies of solid tumors.
Cas No. 2254029-91-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $169 | - | In Stock | |
| 5 mg | $448 | - | In Stock | |
| 10 mg | $715 | - | In Stock | |
| 25 mg | $1,080 | - | In Stock | |
| 50 mg | $1,460 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Alsevalimab (FPA-150) is a humanized monoclonal antibody that targets B7-H4. Alsevalimab specifically binds to B7-H4 on the surface of tumor and immune cells, blocking its inhibitory signals on T-cell activation, reversing the immunosuppressive state of the tumor microenvironment, and activating the proliferation and tumor-killing functions of effector T cells. Alsevalimab also mediates ADCC effects, synergistically enhancing antitumor immunity. Alsevalimab is suitable for use in studies of solid tumors. |
| Synonyms | FPA-150, FPA150, Anti-B7-H4 antibody |
| Reactivity | Human |
| Verified Activity | Immobilized Human B7-H4 Protein (ECD, His) at 2 μg/mL (30 μL/well) can bind Alsevalimab. The EC50 is 0.008484 μg/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | B7-H4/VTCN1 |
| Molecular Weight | 144.78 kDa |
| Cas No. | 2254029-91-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Alsevalimab chemical structure | Alsevalimab molecular weight
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