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Diethylmaleate

Name: Diethylmaleate
Brand: TargetMol
SKU: T21480
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21480Cas No. 141-05-9

Alias Maleic acid, diethyl ester, DIETHYL MALEATE

Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

Diethylmaleate

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Catalog No. T21480Alias Maleic acid, diethyl ester, DIETHYL MALEATECas No. 141-05-9

Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$73	In Stock	In Stock
1 g	$98	-	In Stock
5 g	$155	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB.
In vitro	Diethylmaleate and iodoacetate in combination caused augmented damage to astrocytes in a time- and concentration-dependent manner[1].
In vivo	In TR- rats, in spite of a dilatation of the Golgi apparatus and of the endoplasmic reticulum. It is unlikely that the alterations in the Golgi apparatus (and the endoplasmic reticulum) induced by diethylmaleate play a role in the canalicular secretion of diethylmaleate.
Synonyms	Maleic acid, diethyl ester, DIETHYL MALEATE

Chemical Properties

Molecular Weight	172.18
Formula	C₈H₁₂O₄
Cas No.	141-05-9
Smiles	C(/C=C\C(OCC)=O)(OCC)=O
Relative Density.	1.066. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (348.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 8 mg/mL (46.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8079 mL	29.0394 mL	58.0788 mL	290.3938 mL
5 mM	1.1616 mL	5.8079 mL	11.6158 mL	58.0788 mL
10 mM	0.5808 mL	2.9039 mL	5.8079 mL	29.0394 mL
20 mM	0.2904 mL	1.4520 mL	2.9039 mL	14.5197 mL
50 mM	0.1162 mL	0.5808 mL	1.1616 mL	5.8079 mL
100 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc