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Nomifensine maleate

Name: Nomifensine maleate
Brand: TargetMol
SKU: T7070
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7070Cas No. 32795-47-4

Alias Nomifensine (maleate), (±)-Nomifensine maleat

Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.

Nomifensine maleate

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Purity: 98.46%

Catalog No. T7070Alias Nomifensine (maleate), (±)-Nomifensine maleatCas No. 32795-47-4

Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$45	In Stock	In Stock
50 mg	$64	In Stock	In Stock
100 mg	$106	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.46%

Appearance:solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Nomifensine maleate AI Summary

Nomifensine maleate exhibits a broad range of bioactivities and potential therapeutic applications. It demonstrates antiplasmodial activity against different strains of Plasmodium falciparum with IC50 values ranging from 2511.89 nM to 12589.25 nM after 72 hours, making it a possible candidate for antimalarial treatment with varying efficacy across different strains. Additionally, the compound shows potency in inhibiting the Menin-MLL interaction in leukemias, modulating Lamin A splicing and SMN2 expression, enhancing PMP22 expression/activity, and inhibiting the Influenza NS1 protein and DNA Polymerase Beta. It also inhibits Histone Lysine Methyltransferase G9a, the ERK Signaling Pathway, APE1, Endonuclease IV, Pin1, TDP-43 activity, and the SUMO protease SENP1. Nomifensine maleate acts as a potential general anesthetic, blocks the entry of Ebola and Marburg viruses into cells, and demonstrates significant inhibition of sodium fluorescein uptake in OATP1B3/1B1-transfected CHO cells. Furthermore, it shows an inhibitory effect on the replication of SARS-CoV-2 in Vero E6 cells, though with lower activity compared to arbidol. Overall, Nomifensine maleate is a multifaceted agent with promising applications in treating various diseases and conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used in adult attention deficit disorder.
Synonyms	Nomifensine (maleate), (±)-Nomifensine maleat

Chemical Properties

Molecular Weight	354.4
Formula	C₂₀H₂₂N₂O₄
Cas No.	32795-47-4
Smiles	OC(=O)\C=C/C(O)=O.CN1CC(c2ccccc2)c2cccc(N)c2C1
Relative Density.	1.114g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (225.73 mM), Sonication is recommended.

H2O: 2.2 mg/mL (6.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8217 mL	14.1084 mL	28.2167 mL	141.0835 mL
5 mM	0.5643 mL	2.8217 mL	5.6433 mL	28.2167 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2822 mL	1.4108 mL	2.8217 mL	14.1084 mL
20 mM	0.1411 mL	0.7054 mL	1.4108 mL	7.0542 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8217 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4108 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc