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Anti-CXCR3 Antibody (2V679)

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Catalog No. TMAB-04803

Anti-CXCR3 Antibody (2V679) is a Mouse antibody targeting CXCR3. Anti-CXCR3 Antibody (2V679) can be used in WB.

Anti-CXCR3 Antibody (2V679)

Anti-CXCR3 Antibody (2V679)

😃Good
Catalog No. TMAB-04803
Anti-CXCR3 Antibody (2V679) is a Mouse antibody targeting CXCR3. Anti-CXCR3 Antibody (2V679) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2207-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5277-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-CXCR3 Antibody (2V679) is a Mouse antibody targeting CXCR3. Anti-CXCR3 Antibody (2V679) can be used in WB.
Clone
2V679
Reactivity
Human
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Monoclonal
Host SpeciesMouse
Subcellular LocalizationCell membrane; Multi-pass membrane protein.
Tissue SpecificityIsoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
ConstructionHybridoma Monoclonal Antibody
PurificationProtein A purified
AppearanceLyophilized or Liquid
Research BackgroundThis gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
Antigen Details
Immunogen
Recombinant Protein: human CXCR3 protein
Antigen Species
Human
Gene Name
CXCR3
Gene ID
2833
Protein Name
C-X-C chemokine receptor type 3
Uniprot ID
P49682
Function
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
Isoform 3 mediates the activity of CXCL11.
Chemical Properties
Molecular WeightTheoretical: 41 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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