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Taurolidine

Name: Taurolidine
Brand: TargetMol
SKU: T7533
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7533Cas No. 19388-87-5

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.

Taurolidine

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Purity: 99.81%

Catalog No. T7533Cas No. 19388-87-5

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	-	In Stock
100 mg	$52	-	In Stock
500 mg	$139	-	In Stock
1 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.81%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
In vitro	Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
In vivo	In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
Cell Research	In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
Animal Research	In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].

Chemical Properties

Molecular Weight	284.36
Formula	C₇H₁₆N₄O₄S₂
Cas No.	19388-87-5
Smiles	O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1
Relative Density.	1.466 g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (175.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5167 mL	17.5833 mL	35.1667 mL	175.8335 mL
5 mM	0.7033 mL	3.5167 mL	7.0333 mL	35.1667 mL
10 mM	0.3517 mL	1.7583 mL	3.5167 mL	17.5833 mL
20 mM	0.1758 mL	0.8792 mL	1.7583 mL	8.7917 mL
50 mM	0.0703 mL	0.3517 mL	0.7033 mL	3.5167 mL
100 mM	0.0352 mL	0.1758 mL	0.3517 mL	1.7583 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc