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Facinicline hydrochloride

Name: Facinicline hydrochloride
Brand: TargetMol
SKU: T28531
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28531Cas No. 677305-02-1

Alias RG3487

Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.

Facinicline hydrochloride

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Purity: 98.70%

Catalog No. T28531Alias RG3487Cas No. 677305-02-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$179	In Stock	In Stock
25 mg	$315	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.70%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.
Targets&IC50	5-HT3 receptor:1.2 nM (Ki), α7 nAChR:6 nM (Ki)
In vitro	Facinicline hydrochloride exhibits antagonist properties at the serotonin 3 receptor in oocytes(IC50 = 2.8 μM) and N1E-115 cells(IC50 = 32.7 μM)[2].Facinicline hydrochloride activates human α7 nAChRs in oocytes(EC50 = 0.8 μM) and QM7 cells(EC50 = 7.7 μM)[2].
In vivo	In Male Sprague-Dawley rats, Facinicline hydrochloride (0.1–10 mg/kg p.o.) selectively enhances object recognition memory[1]. Facinicline hydrochloride improves object recognition memory in rats after acute(1.0 mg/kg p.o.) or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range[2].
Synonyms	RG3487

Chemical Properties

Molecular Weight	306.79
Formula	C₁₅H₁₉ClN₄O
Cas No.	677305-02-1
Smiles	Cl.O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (325.96 mM), Sonication is recommended.

DMSO: 125 mg/mL (407.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2596 mL	16.2978 mL	32.5956 mL	162.9779 mL
5 mM	0.6519 mL	3.2596 mL	6.5191 mL	32.5956 mL
10 mM	0.3260 mL	1.6298 mL	3.2596 mL	16.2978 mL
20 mM	0.1630 mL	0.8149 mL	1.6298 mL	8.1489 mL
50 mM	0.0652 mL	0.3260 mL	0.6519 mL	3.2596 mL
100 mM	0.0326 mL	0.1630 mL	0.3260 mL	1.6298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc