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Facinicline hydrochloride

Name: Facinicline hydrochloride
Brand: TargetMol
SKU: T28531
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28531Cas No. 677305-02-1

Alias RG3487

Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.

Facinicline hydrochloride

🥰Excellent

Purity: 98.70%

Catalog No. T28531Alias RG3487Cas No. 677305-02-1

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$118	In Stock
10 mg	$179	In Stock
25 mg	$315	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.70%

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COA LCMS

Product Introduction

Bioactivity

Description	Facinicline hydrochloride (RG3487) is both a novel nicotinic alpha-7 receptor (alpha7nAChR) partial agonist (Ki = 6 nM) and an antagonist of 5-HT3(Ki = 1.2 nM). Facinicline hydrochloride improves cognition and sensorimotor gating in rodents.
Targets&IC50	α7 nAChR:6 nM (Ki), 5-HT3 receptor:1.2 nM (Ki)
In vitro	Facinicline hydrochloride exhibits antagonist properties at the serotonin 3 receptor in oocytes(IC50 = 2.8 μM) and N1E-115 cells(IC50 = 32.7 μM)[2].Facinicline hydrochloride activates human α7 nAChRs in oocytes(EC50 = 0.8 μM) and QM7 cells(EC50 = 7.7 μM)[2].
In vivo	In Male Sprague-Dawley rats, Facinicline hydrochloride (0.1–10 mg/kg p.o.) selectively enhances object recognition memory[1]. Facinicline hydrochloride improves object recognition memory in rats after acute(1.0 mg/kg p.o.) or repeated (10 day) administration at brain and plasma concentrations in the low-nanomolar range[2].
Synonyms	RG3487

Chemical Properties

Molecular Weight	306.79
Formula	C₁₅H₁₉ClN₄O
Cas No.	677305-02-1
Smiles	Cl.O=C(N[C@@H]1CN2CCC1CC2)c1n[nH]c2ccccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (325.96 mM), Sonication is recommended.

DMSO: 125 mg/mL (407.44 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2596 mL	16.2978 mL	32.5956 mL	162.9779 mL
5 mM	0.6519 mL	3.2596 mL	6.5191 mL	32.5956 mL
10 mM	0.3260 mL	1.6298 mL	3.2596 mL	16.2978 mL
20 mM	0.1630 mL	0.8149 mL	1.6298 mL	8.1489 mL
50 mM	0.0652 mL	0.3260 mL	0.6519 mL	3.2596 mL
100 mM	0.0326 mL	0.1630 mL	0.3260 mL	1.6298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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