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Nitrofen

Name: Nitrofen
Brand: TargetMol
SKU: T39280
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39280Cas No. 1836-75-5

Nitrofen is a selective contact herbicide that acts as an inhibitor of protoporphyrinogen oxidase and retinal dehydrogenase.

Nitrofen

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Purity: 99.92%

Catalog No. T39280Cas No. 1836-75-5

Nitrofen is a selective contact herbicide that acts as an inhibitor of protoporphyrinogen oxidase and retinal dehydrogenase.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$38	In Stock	In Stock
1 g	$54	In Stock	In Stock
2 g	$76	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.92%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Nitrofen AI Summary

Nitrofen exhibits a variety of bioactivities and has significant implications for multiple biological pathways and species. This compound shows hepatotoxicity in mice and has been assessed for its carcinogenic potency with a pTD50 value of 3.203. It is a multifaceted modulator of signal transduction pathways, acting as an agonist towards retinoid X receptor alpha (1258.9 nM), farnesoid X receptor (17782.8 nM), antioxidant response element (ARE) through Nrf2-dependent transcriptional activity (61130.6 nM), and human pregnane X receptor (PXR) signaling (28183.8 nM). Additionally, it antagonizes androgen receptor signaling with a potency of 19952.6 nM. In plant systems, Nitrofen inhibits chlorophyll biosynthesis and autotrophic growth in Chlorella salina and suppresses protoporphyrinogen oxidase activity in Gossypium hirsutum seedlings. This results in phytotoxicity, including chlorophyll biosynthesis inhibition and cotyledon damage manifesting as green spots under light conditions. Moreover, Nitrofen has shown antiviral properties by inhibiting SARS-CoV-2 3CL-Pro protease by 16.29% at a concentration of 20 µM through a FRET assay. It also inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells by -0.11% following a 10 µM exposure for 48 hours to 0.01 MOI SARS-CoV-2 virus, based on high content imaging assessments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Nitrofen is a selective contact herbicide that acts as an inhibitor of protoporphyrinogen oxidase and retinal dehydrogenase.

Chemical Properties

Molecular Weight	284.09
Formula	C₁₂H₇Cl₂NO₃
Cas No.	1836-75-5
Smiles	[O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1
Relative Density.	1.3 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (193.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5200 mL	17.6001 mL	35.2001 mL	176.0006 mL
5 mM	0.7040 mL	3.5200 mL	7.0400 mL	35.2001 mL
10 mM	0.3520 mL	1.7600 mL	3.5200 mL	17.6001 mL
20 mM	0.1760 mL	0.8800 mL	1.7600 mL	8.8000 mL
50 mM	0.0704 mL	0.3520 mL	0.7040 mL	3.5200 mL
100 mM	0.0352 mL	0.1760 mL	0.3520 mL	1.7600 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc