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Spinosyn A
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Catalog No. T21495Cas No. 131929-60-7
Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and is an active ingredient in several commercial insecticides.
Spinosyn A
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Purity: 99.85%
Catalog No. T21495Cas No. 131929-60-7
Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and is an active ingredient in several commercial insecticides.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $178 | In Stock | In Stock | |
| 2 mg | $263 | In Stock | In Stock | |
| 5 mg | $437 | In Stock | In Stock | |
| 10 mg | $592 | In Stock | In Stock | |
| 25 mg | $918 | In Stock | In Stock | |
| 50 mg | $1,180 | In Stock | In Stock | |
| 100 mg | $1,660 | - | In Stock | |
| 200 mg | $2,250 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $678 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.85%
Appearance:Solid
Color:White
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Product Introduction
Spinosyn A AI Summary
Spinosyn A exhibits a broad range of bioactivities, demonstrating both insecticidal and antiproliferative properties. In terms of its insecticidal activity, Spinosyn A is effective against beet armyworm and tobacco budworm eggs, with minimum emergent larvicide concentrations of 3.0 ppm and 0.4 ppm, respectively, observed after 6 to 7 days. It also inhibits the growth of beet armyworm eggs with a minimum inhibitory concentration (MIC) of 0.02 ppm at 28°C in a lepidopteran diet assay. Additionally, the compound shows significant activity against various pests such as cotton aphid, green peach aphid, sweet potato whitefly, cabbage looper, and two-spotted spider mites, with efficacy indicated by LC50 values.
Regarding its antiproliferative action, Spinosyn A is effective against several human cancer cell lines, including MCF7, HCT116, NCI-H460, and U87MG. It displays different levels of potency, with IC50 values of 17900.0 nM for MCF7 cells, 11100.0 nM for HCT116 cells, 67500.0 nM for NCI-H460 cells, and 96500.0 nM for U87MG cells after 48 hours based on the MTT assay. The compound induces apoptosis in NCI-H460 cells, as observed through flow cytometric analysis using Annexin V-FITC/propidium iodide staining, affecting necrotic, late apoptotic, early apoptotic, and viable cells at varying concentrations..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Spinosyn A is a polyketide-derived macrolide produced by Saccharopolyspora spinosa and is an active ingredient in several commercial insecticides. |
| Molecular Weight | 731.96 |
| Formula | C41H65NO10 |
| Cas No. | 131929-60-7 |
| Smiles | [H][C@@]12C[C@H](C[C@@]1([H])[C@]1([H])C=C3C(=O)[C@H](C)[C@H](CCC[C@H](CC)OC(=O)C[C@@]3([H])[C@]1([H])C=C2)O[C@@]1([H])CC[C@@H]([C@@H](C)O1)N(C)C)O[C@]1([H])O[C@@H](C)[C@H](OC)[C@@H](OC)[C@H]1OC |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (13.66 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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